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dc.contributor.author황승용-
dc.date.accessioned2017-05-25T02:11:46Z-
dc.date.available2017-05-25T02:11:46Z-
dc.date.issued2015-09-
dc.identifier.citationBIOCHIP JOURNAL, v. 9, NO 3, Page. 259-267en_US
dc.identifier.issn1976-0280-
dc.identifier.issn2092-7843-
dc.identifier.urihttps://link.springer.com/article/10.1007/s13206-015-9310-4-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/27442-
dc.description.abstractHumans can absorb volatile organic compounds (VOCs), such as ethylbenzene (EB), via inhalation resulting in various effects such as hepatotoxicity and even carcinogenicity. Because occupational EB exposure occurs frequently in the synthetic rubber and plastic industry, its toxicity has been previously reported by various in vitro as well as in vivo animal studies. EB has also been classified as a group 2B possible carcinogen by the IARC. However, these studies investigated the toxicity of EB used a much higher dose than expected occupational exposure. Thus the results are likely to be far away from to be the basis for the validation of the toxicity of the EB exposure. Because the previous studies examine only phenotypes, it is still unclear what and how EB affects physiological pathways in the human body. Using microarray platform, we investigated the gene expression profiles and genomic methylation patterns of 66 human blood samples from employees of local plants that use EB. The affected genes were functionally analyzed using the DAVID Tool and IPA. The methylation array demonstrated that, compared to the control group, a total of 1446 genes were hypermethylated and 60 genes were hypomethylated. Among the 378 differentially expressed genes, 12 had proper epigenetic correlation with the altered methylation patterns. Our study demonstrated how EB exposure affects the human genome by investigating the gene expression profiles and DNA methylation profiles of blood cells. We expect that our results will help establish the genomic basis of the effect of EB exposure on humans.en_US
dc.description.sponsorshipThe samples were given by Korea University Medical Center (IRB #AS 14039) and this work was supported by the Korea Ministry of Environment as a "Converging technology project" (Project No. 201400165002). Microarray platforms were provided by BioCore Co., Ltd (Seoul, Korea).en_US
dc.language.isoenen_US
dc.publisherKOREAN BIOCHIP SOCIETY-KBCSen_US
dc.subjectVolatile organic compounds (VOCs)en_US
dc.subjectEthylbenzene (EB)en_US
dc.subjectGene expression profilingen_US
dc.subjectDNA methylation profilingen_US
dc.subjectMicroarrayen_US
dc.titleIntegrative Analyses of Differential Gene Expression and DNA Methylation of Ethylbenzene-exposed Workersen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume9-
dc.identifier.doi10.1007/s13206-015-9310-4-
dc.relation.page259-267-
dc.relation.journalBIOCHIP JOURNAL-
dc.contributor.googleauthorKim, Gi Won-
dc.contributor.googleauthorHong, Ji Young-
dc.contributor.googleauthorYu, So-Yeon-
dc.contributor.googleauthorAhn, Jeong Jin-
dc.contributor.googleauthorKim, Youngjoo-
dc.contributor.googleauthorSon, Sang Wook-
dc.contributor.googleauthorPark, Jong-Tae-
dc.contributor.googleauthorHwang, Seung Yong-
dc.relation.code2015006188-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidsyhwang-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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