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The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a preliminary study

Title
The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a preliminary study
Author
노성원
Keywords
Alcohol dependence; Cognitive function; Brain-derived neurotrophic factor
Issue Date
2015-09
Publisher
BIOMED CENTRAL LTD
Citation
ANNALS OF GENERAL PSYCHIATRY, v. 14, Page. 1-10
Abstract
Background: As a neurotoxic substance, alcohol can induce neurodegenesis in the brain. Alcohol-dependent patients' cognitive functioning can be affected by chronic alcohol use. In addition, brain-derived neurotrophic factor (BDNF) is known to reflect the status of neuroadaptive changes. The purpose of this study was to investigate the relationship between cognitive functions and BDNF in alcohol-dependent patients. Methods: The subjects were 39 alcohol-dependent patients. BDNF was measured using an enzyme-linked immunosorbent assay kit. We examined clinical features and administered the Korean version of Alcohol Dependence Scale. We also used the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) to measure cognitive functioning. Then, we determined the relationships between BDNF and various parts of the CERAD. Results: The performance of alcohol-dependent patients proved stable in most parts of the CERAD. Within the different parts of the CERAD, only Trail Making Test B correlated with BDNF. Trail Making Test specifically assesses executive functions. Conclusions: BDNF might play an important role in the detection of neurocognitive function among individuals with alcohol dependence.
URI
https://annals-general-psychiatry.biomedcentral.com/articles/10.1186/s12991-015-0065-zhttp://hdl.handle.net/20.500.11754/27419
ISSN
1744-859X
DOI
10.1186/s12991-015-0065-z
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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