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dc.identifier.citationCLINICAL NUTRITION, v. 35, no. 5, Page. 1127-1134en_US
dc.description.abstractBackground & aim: Understanding the lifestyle and genetic factors that affect pulse wave velocity (PWV) may provide clues to preventing atherosclerotic cardiovascular events. The aim of this study is to investigate genome-wide genetic and dietary calcium (Ca) intake interaction effects on brachial ankle pulse wave velocity (baPWV). Methods: The baPWV was measured, and Ca intake was quantified by administering a food frequency questionnaire (FFQ) to 3198 participants, which included men and women (>= 40 years) from the Korean Multi-Rural communities Cohort study (MRCohort). The interaction effects of dietary Ca intake and 19 single-nucleotide polymorphisms (SNPs) on baPWV were assessed using the general linear models. Results: Dietary Ca intake was not significantly associated with baPWV or any type of SNP among the subjects herein. In men, however, the adducinl (ADD1) rs4961_C SNP had a significant dietary Ca intake dependent effect on mean baPWV (P-interaction = 0.002). In women, the interaction of zinc finger proteins 618 (ZNF618) rs10817542_A with dietary Ca intake played a significant and key role in mean baPWV (P-interaction = 0.001). In the results of ADD1 rs4961_C in men and ZNF618 rs10817542_A in women, the minor allele-lowest Ca intake tertile (T1) group had significantly higher mean baPWV value than other subgroups of Ca intake tertile-genotype cross -classification whereas genotype was not a significant effector on mean baPWV values among highest Ca intake subgroups (T3). Conclusions: The baPWV, a phenotype of arterial stiffness, can be modulated in subjects through regulation of dietary Ca intake, particularly in subjects with more vulnerable genotypes. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by biospecimens and data from the Korean Genome Analysis Project (4845-301) and the Korean Genome and Epidemiology Study (4851-302), which are supported by the Korea Centers for Disease Control and Prevention, Republic of Korea. This study was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant NRF-2012R1A1A2001930). The funders played no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.en_US
dc.subjectDietary calcium intakeen_US
dc.subjectSingle-nucleotide polymorphismsen_US
dc.subjectArterial stiffnessen_US
dc.subjectGene-diet interactionen_US
dc.titleGene and dietary calcium interaction effects on brachial-ankle pulse wave velocityen_US
dc.relation.journalCLINICAL NUTRITION-
dc.contributor.googleauthorChoi, SeongIl-
dc.contributor.googleauthorJung, Sukyoung-
dc.contributor.googleauthorKim, Mi Kyung-
dc.contributor.googleauthorShin, Jinho-
dc.contributor.googleauthorShin, Min-Ho-
dc.contributor.googleauthorShin, Dong Hoon-
dc.contributor.googleauthorLee, Young-Hoon-
dc.contributor.googleauthorChun, Byung-Yeol-
dc.contributor.googleauthorHong, Kyung-Won-
dc.contributor.googleauthorHwang, Joo-Yeon-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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