Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현주 | - |
dc.date.accessioned | 2017-05-22T01:45:16Z | - |
dc.date.available | 2017-05-22T01:45:16Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE, v. 30, NO 9, Page. 1295-1301 | en_US |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://synapse.koreamed.org/search.php?where=aview&id=10.3346/jkms.2015.30.9.1295&code=0063JKMS&vmode=FULL | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/27361 | - |
dc.description.abstract | Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1 alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants are prematurely exposed to hyperoxia, which can halt hypoxia-driven lung maturation. We were to investigate whether the HIF-1 alpha inducer, deferoxamine (DFX) can improve alveolarization in a rat model of bronchopulmonary dysplasia (BPD). A rat model of BPD was produced by intra-amniotic lipopolysaccharide (LPS) administration and postnatal hyperoxia (85% for 7 days), and DFX (150 mg/kg/d) or vehicle was administered to rat pups intraperitoneally for 14 days. On day 14, the rat pups were sacrificed and their lungs were removed and examined. A parallel in vitro study was performed with a human small airway epithelial cell line to test whether DFX induces the expression of HIF-1 alpha and its target genes. Alveolarization and pulmonary vascular development were impaired in rats with BPD. However, DFX significantly ameliorated these effects. Immunohistochemical analysis showed that HIF-1 alpha was significantly upregulated in the lungs of BPD rats treated with DFX. DFX was also found to induce HIF-1 alpha in human small airway epithelial cells and to promote the expression of HIF-1 alpha target genes. Our data suggest that DFX induces and activates HIF-1 alpha, thereby improving alveolarization and vascular distribution in the lungs of rats with BPD. | en_US |
dc.description.sponsorship | This work was supported by the SNUBH Research Fund (grant No. 03-2007-007) and by Basic Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2010-0021644). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | en_US |
dc.subject | Alveolarization | en_US |
dc.subject | Bronchopulmonary Dysplasia | en_US |
dc.subject | Deferoxamine | en_US |
dc.subject | Hypoxia-Inducible Factor | en_US |
dc.title | Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1 alpha in a Rat Model of Bronchopulmonary Dysplasia | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 30 | - |
dc.identifier.doi | 10.3346/jkms.2015.30.9.1295 | - |
dc.relation.page | 1295-1301 | - |
dc.relation.journal | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.contributor.googleauthor | Choi, Chang Won | - |
dc.contributor.googleauthor | Lee, Juyoung | - |
dc.contributor.googleauthor | Lee, Hyun Ju | - |
dc.contributor.googleauthor | Park, Hyoung-Sook | - |
dc.contributor.googleauthor | Chun, Yang-Sook | - |
dc.contributor.googleauthor | Kim, Beyong Il | - |
dc.relation.code | 2015003059 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | blesslee77 | - |
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