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AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma

Title
AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma
Author
이경근
Keywords
Carcinoma; Hepatocellular; Prognosis; Biological Markers
Issue Date
2015-09
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v. 30, NO 9, Page. 1253-1253
Abstract
Despite a low risk of liver failure and preserved liver function, non-cirrhotic hepatocellular carcinoma (HCC) has a poor prognosis. In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of AROS were measured in tumor and non-tumor tissues obtained from 283 non-cirrhotic HCC patients. AROS expression was exclusively up-regulated in recurrent tissues from the non-cirrhotic HCC patients (P = 0.015) and also in tumor tissues irrespective of tumor stage (P ˂ 0.001) or BCLC stage (P ˂ 0.001). High mRNA levels of AROS were statistically significantly associated with tumor stage (P ˂ 0.001), BCLC stage (P = 0.007), alpha fetoprotein (AFP) level (P = 0.013), microvascular invasion (P = 0.001), tumor size (P = 0.036), and portal vein invasion (P = 0.005). Kaplan-Meir curve analysis demonstrated that HCC patients with higher AROS levels had shorter disease-free survival (DFS) in both the short-term (P ˂ 0.001) and long-term (P = 0.005) compared to those with low AROS. Cox regression analysis demonstrated that AROS is a significant predictor for DFS along with large tumor size, tumor multiplicity, vascular invasion, and poor tumor differentiation, which are the known prognostic factors. In conclusion, AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma.
URI
https://synapse.koreamed.org/search.php?where=aview&id=10.3346/jkms.2015.30.9.1253&code=0063JKMS&vmode=FULLhttp://hdl.handle.net/20.500.11754/27304
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2015.30.9.1253
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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