Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2017-05-02T06:15:17Z | - |
dc.date.available | 2017-05-02T06:15:17Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | TOXICOLOGY AND APPLIED PHARMACOLOGY, v. 286, NO 3, Page. 143-150 | en_US |
dc.identifier.issn | 0041-008X | - |
dc.identifier.issn | 1096-0333 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0041008X15001179 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/27126 | - |
dc.description.abstract | Poor prognosis of breast cancer patients is closely associated with metastasis and relapse. There is substantial evidence supporting that cancer stem-like cells (CSCs) are primarily responsible for relapse in breast cancer after anticancer treatment. However, there is a lack of suitable drugs that target breast cancer stem-like cells (BCSCs). Here, we report that phloroglucinol (PG), a natural phlorotannin component of brown algae, suppresses sphere formation, anchorage-independent colony formation and in vivo tumorigenicity. In line with these observations, treatment with PG also decreased CD44(+) cancer cell population as well as expression of CSC regulators such as Sox2, CD44, Oct4, Notch2 and beta-catenin. Also, treatment with PG sensitized breast cancer cells to anticancer drugs such as cisplatin, etoposide, and taxol as well as to ionizing radiation. Importantly, PG inhibited KRAS and its downstream PI3K/AKT and RAF-1/ERK signaling pathways that regulate the maintenance of CSCs. Taken together, our findings implicate PG as a good candidate to target BCSCs and to prevent the disease relapse. (C) 2015 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation (NRF) and Ministry of Science, ICT & Future Planning, Korean Government, through its National Nuclear Technology Program (NRF-2013M2A2A7066345) and Converging Research Center Program (NRF-2013K000283). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.subject | Phloroglucinol | en_US |
dc.subject | Breast cancer stem-like cells | en_US |
dc.subject | Relapse | en_US |
dc.subject | Resistance to anticancer treatment | en_US |
dc.subject | KRAS | en_US |
dc.subject | Anticancer activity | en_US |
dc.title | Novel anticancer activity of phloroglucinol against breast cancer stem-like cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 286 | - |
dc.identifier.doi | 10.1016/j.taap.2015.03.026 | - |
dc.relation.page | 143-150 | - |
dc.relation.journal | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.contributor.googleauthor | Kim, Rae-Kwon | - |
dc.contributor.googleauthor | Uddin, Nizam | - |
dc.contributor.googleauthor | Hyun, Jin-Won | - |
dc.contributor.googleauthor | Kim, Changil | - |
dc.contributor.googleauthor | Suh, Yongjoon | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.relation.code | 2015001464 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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