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Anti-Reflux Ureteral Stent with Polymeric Flap Valve Using Three-Dimensional Printing: An In Vitro Study

Title
Anti-Reflux Ureteral Stent with Polymeric Flap Valve Using Three-Dimensional Printing: An In Vitro Study
Author
문홍상
Keywords
CLINICAL USE; EXPERIENCE; SYMPTOMS; REFLUX; COMPLICATIONS; FLOW
Issue Date
2015-08
Publisher
MARY ANN LIEBERT
Citation
JOURNAL OF ENDOUROLOGY, v. 29, NO 8, Page. 933-938
Abstract
Purpose: This article aims to describe the design of an anti-reflux ureteral stent with a polymeric flap valve and the fabrication methods using three-dimensional (3D) printing. The stent effectively prevents backward flow with a negligible reduction in forward flow. Fabrication of miniaturized valves was easy with high precision and rapid prototyping. Materials and Methods: The proposed stent comprised a 7F Double-J (DJ) stent and a polymeric flap valve. The valve was made of Tango Plus FLX980 and was fabricated using a 3D printer. Two types of stent were prepared for in vitro tests: DJ stents with (1) an uncoated valve (UCV) stent and (2) a parylene C coated valve (PCV) stent for enhanced biocompatibility. The flow characteristics of each stent were evaluated considering flow direction, parylene coating, and stent side holes, and were compared to the intact DJ stent. Results: The forward flow rate for the distal portion of the UCV and PCV stents was 9.8mL/min and 7.8mL/min at applied pressure of 15cm H2O (normal anterograde pressure in patients with stents), respectively. Backward flow rate for the distal portion of the UCV and PCV stents was decreased by 28 times and 8 times at applied pressure of 50cm H2O (maximum bladder pressure), respectively, compared with the distal portion of the intact DJ stent. Forward flow rates of whole stents were 22.2mL/min (UCV stent) and 20.0mL/min (PCV stent) at applied pressure of 15cm H2O, and backward flow rates of whole UCV and PCV stents were decreased by 8.3 times and 4.0 times at applied pressure of 50cm H2O, respectively, compared with the intact DJ stent. Conclusions: The anti-reflux ureteral stent was successfully designed and fabricated using a 3D printer. In vitro studies showed that the stent effectively prevented backward flow while minimizing reduction in forward flow.
URI
http://online.liebertpub.com/doi/abs/10.1089/end.2015.0154http://hdl.handle.net/20.500.11754/27109
ISSN
0892-7790; 1557-900X
DOI
10.1089/end.2015.0154
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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