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The association between carbon and nitrogen stable isotope ratios of human hair and metabolic syndrome

Title
The association between carbon and nitrogen stable isotope ratios of human hair and metabolic syndrome
Author
김미경
Keywords
Stable isotope ratio; Nitrogen; Carbon; Metabolic syndrome
Issue Date
2015-08
Publisher
ELSEVIER SCIENCE BV
Citation
CLINICA CHIMICA ACTA, v. 450, Page. 72-77
Abstract
Background: It has been reported that stable isotope ratios can be used as biomarkers for animal protein intake. Meat consumption and high protein intake could be risk factors for metabolic disorders. We investigated whether the stable isotope ratios of carbon and nitrogen are associated with metabolic syndrome. Methods: We conducted a cross-sectional study of 399 subjects (233 men and 166 women). Hair samples from 399 subjects were measured for stable isotope ratios of carbon (delta C-13) and nitrogen (delta N-15). Results: The delta N-15 values progressively increased with the number of components of the metabolic syndrome present in study subjects (P for trend 0.047). In multivariable models, delta N-15 values were positively associated with the presence of metabolic syndrome (odds ratio, 1.53; 95% confidence interval, 1.09-2.14), whereas delta C-13 values were not (odds ratio, 0.97; 95% confidence interval, 0.72-130). The odds ratio (95% confidence interval) for metabolic syndrome comparing the highest to the lowest quartiles of delta N-15 values was 2.64(1.17-5.92). Conclusions: The nitrogen, but not carbon, stable isotopic ratio of hair is independently associated with the presence of metabolic syndrome. The hair delta N-15 value might be a surrogate marker for clustering of risk factors in metabolic syndrome. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0009898115003617http://hdl.handle.net/20.500.11754/27036
ISSN
0009-8981; 1873-3492
DOI
10.1016/j.cca.2015.07.032
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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