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dc.contributor.author신정훈-
dc.date.accessioned2017-04-19T07:28:12Z-
dc.date.available2017-04-19T07:28:12Z-
dc.date.issued2015-08-
dc.identifier.citationTISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 13, no. 3, page. 297-303en_US
dc.identifier.issn1738-2696-
dc.identifier.issn2212-5469-
dc.identifier.urihttps://link.springer.com/article/10.1007/s13770-016-9054-9-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26834-
dc.description.abstractA systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2014).en_US
dc.language.isoenen_US
dc.publisherKOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOCen_US
dc.subjectGranulocyte-colony stimulating factoren_US
dc.subjectWound healingen_US
dc.subjectLocal injectionen_US
dc.titleLocal Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Modelen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s13770-016-9054-9-
dc.relation.journalTISSUE ENGINEERING AND REGENERATIVE MEDICINE-
dc.contributor.googleauthorShen, Guang-Yin-
dc.contributor.googleauthorPark, In-Hwa-
dc.contributor.googleauthorSong, Yi-Sun-
dc.contributor.googleauthorJoo, Hyun-Woo-
dc.contributor.googleauthorLee, Yonggu-
dc.contributor.googleauthorShin, Jeong-Hun-
dc.contributor.googleauthorKim, Kyung-Soo-
dc.contributor.googleauthorKim, Hyuck-
dc.relation.code2015009287-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhyapex-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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