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dc.contributor.author오재원-
dc.date.accessioned2017-04-19T02:32:50Z-
dc.date.available2017-04-19T02:32:50Z-
dc.date.issued2015-08-
dc.identifier.citationCELLULAR IMMUNOLOGY, v. 298, NO 1-2, Page. 9-17en_US
dc.identifier.issn0008-8749-
dc.identifier.issn1090-2163-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0008874915300095-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26804-
dc.description.abstractThe purpose of this study was to identify the role of phospholipase D1 (PLD1) in Amb a 1-induced IL-5 and IL-13 expression. When BEAS-2B cells were stimulated with Amb a 1, PLD activity increased, and knockdown of PLD1 decreased Amb a 1-induced IL-5 and IL-13 expression. Amb a 1 also activated the PLC gamma/p70S6K/JNK pathway. Furthermore, Amb a 1-induced PLD activation was also attenuated by PLC gamma inhibition, and knockdown of PLD1 decreased Amb a 1-induced activation of P70S6K and JNK. When ATF-2 activity was blocked with ATF-2 siRNA, Amb a 1-induced IL-5 and IL-13 expression was completely abolished, indicating that ATF-2 is a transcriptional factor required for the expression of IL-5 and IL-13 in response to Amb a 1. Taken together, we suggest that PLD1 acts as an important regulator in Amb a 1-induced expression of IL-5 and IL-13 via a PLC gamma/p70S6K/JNK/ATF-2 pathway in BEAS-2B cells. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2013R1A2A2A03067895).en_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.subjectAmbrosia artemisiifoliaen_US
dc.subjectPLD1en_US
dc.subjectJNKen_US
dc.subjectp70S6Ken_US
dc.subjectIL-13en_US
dc.subjectIL-5en_US
dc.titlePLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cellsen_US
dc.typeArticleen_US
dc.relation.no1-2-
dc.relation.volume298-
dc.identifier.doi10.1016/j.cellimm.2015.08.003-
dc.relation.page9-17-
dc.relation.journalCELLULAR IMMUNOLOGY-
dc.contributor.googleauthorKim, Joo-Hwa-
dc.contributor.googleauthorChoi, Hye-Jin-
dc.contributor.googleauthorOh, Cheong-Hae-
dc.contributor.googleauthorOh, Jae-Won-
dc.contributor.googleauthorHan, Joong-Soo-
dc.relation.code2015000331-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjaewonoh-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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