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dc.contributor.author박용순-
dc.date.accessioned2017-04-19T00:58:05Z-
dc.date.available2017-04-19T00:58:05Z-
dc.date.issued2015-08-
dc.identifier.citationJOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 26, NO 9, Page. 970-977en_US
dc.identifier.issn0955-2863-
dc.identifier.issn1873-4847-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0955286315001047-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26791-
dc.description.abstractPrevious studies have suggested that estrogen and n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antidepressant-like effects. The purpose of the present study was to determine the interaction between n-3 PUFAs and estrogen, and their neurotrophic mechanism in rats after the forced swimming test (FST). Rats were fed a modified American Institute of Nutrition 93G diet with 0%, 1% or 2% EPA+DHA relative to the total energy intake during 12 weeks. At 8 weeks, rats were ovariectomized and injected with either 17 beta-estradiol-3-benzoate (E-2) or corn oil during the last 3 weeks. Both n-3 PUFA supplementation and E-2 injection increased climbing and decreased immobility during the FST. Serum serotonin concentration was also increased by both n-3 PUFA and E-2. N-3 PUFA and E-2 decreased hippocampal expressions of interleukin (IL)-6 and tumor necrosis factor-alpha, and increased cAMP response element binding protein (CREB), phosphorylated CREB and brain-derived neurotrophic factor (BDNF). N-3 PUFA supplementation decreased hippocampal expression of IL-1 beta only in rats injected with E-2. Both n-3 PUPA supplementation and E-2 injection increased estrogen receptor (ER)-alpha in the hippocampus, but ER-beta was increased only by E-2 injection. Additionally, there was a significant interaction between n-3 PUFA supplementation and E-2 injection on the hippocampal expression of pCREB, suggesting membrane-mediated interaction of n-3 PUFAs and E-2. In conclusion, both n-3 PUFA and E-2 had antidepressant-like effects by regulating serotonergic neurotransmission through BDNF and inflammatory cytokines. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis study was supported by a Korean Research Foundation grant funded by the Korean Government (NRF-2012R1A1A2040553).en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.subject17 beta-Estradiol-3-benzoateen_US
dc.subjectBDNFen_US
dc.subjectForced swimming testen_US
dc.subjectInflammatory cytokinesen_US
dc.subjectN-3 polyunsaturated fatty acidsen_US
dc.subjectRatsen_US
dc.titleN-3 polyunsaturated fatty acids and 17 beta-estradiol injection induce antidepressant-like effects through regulation of serotonergic neurotransmission in ovariectomized ratsen_US
dc.typeArticleen_US
dc.relation.no9-
dc.relation.volume26-
dc.identifier.doi10.1016/j.jnutbio.2015.04.005-
dc.relation.page970-977-
dc.relation.journalJOURNAL OF NUTRITIONAL BIOCHEMISTRY-
dc.contributor.googleauthorJin, Youri-
dc.contributor.googleauthorPark, Yongsoon-
dc.relation.code2015001128-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF HUMAN ECOLOGY[S]-
dc.sector.departmentDEPARTMENT OF FOOD & NUTRITION-
dc.identifier.pidyongsoon-
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COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
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