Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyunsook Kim | - |
dc.date.accessioned | 2017-04-18T02:36:42Z | - |
dc.date.available | 2017-04-18T02:36:42Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | JOURNAL OF FUNCTIONAL FOODS, v. 17, Page. 881-891 | en_US |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1756464615003333 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26751 | - |
dc.description.abstract | The effect of flavonoid-rich wine grape seed flour, a byproduct of winemaking, on global adipose tissue gene expression and obesity-induced insulin resistance was assessed in high fat (HF) diet-induced obese (DIO) mice. DIO mice were fed HF diet supplemented with either partially defatted Chardonnay grape seed flour (ChrSd) or microcrystalline cellulose (MCC, control) for 5 weeks. ChrSd diet suppressed the HF diet-induced increase in total body, liver, and adipose tissue weights with a significant decrease in feed efficiency. ChrSd intake significantly lowered the 2-h insulin and glucose areas under the curve suggesting that ChrSd improves insulin sensitivity and glucose metabolism. Gene expression profiling analysis of adipose tissue from mice fed a ChrSd diet, by exon microarray and RT-PCR, revealed a down-regulation of genes related to oxidative stress, inflammation, immune response, protein carbonylation, and fatty acid synthesis. Conversely, genes related to the scavenging of free radicals, antioxidants, insulin sensitivity, and fatty acid oxidation, were up-regulated. Pathway analysis of microarray data identified genes related to innate immune response, inflammatory response, and infectious disease as being differentially regulated by the ChrSd diet. Thus, ChrSd ameliorates HF-induced obesity, insulin resistance, and glucose intolerance in DIO mice by modulating expression of genes in adipose tissue. (C) 2015 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No.2015R1A2A2A01005017). Many thanks to Sonomaceuticals, LLC/WholeVine Products and their sister company for contribution of grape seed flours and compositional analysis and Glenn E. Bartley for technical assistance. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Flavonoids | en_US |
dc.subject | Grape seed | en_US |
dc.subject | Obesity | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Insulin resistance | en_US |
dc.subject | Glucose intolerance | en_US |
dc.title | Flavonoid-rich Chardonnay grape seed flour supplementation ameliorates diet-induced visceral adiposity, insulin resistance, and glucose intolerance via altered adipose tissue gene expression | en_US |
dc.type | Article | en_US |
dc.relation.volume | 17 | - |
dc.identifier.doi | 10.1016/j.jff.2015.06.039 | - |
dc.relation.page | 881-891 | - |
dc.relation.journal | JOURNAL OF FUNCTIONAL FOODS | - |
dc.contributor.googleauthor | Seo, Kun-Ho | - |
dc.contributor.googleauthor | Kim, Hyunsook | - |
dc.contributor.googleauthor | Chon, Jung-Whan | - |
dc.contributor.googleauthor | Kim, Dong-Hyeon | - |
dc.contributor.googleauthor | Nah, Seung-Yeol | - |
dc.contributor.googleauthor | Arvik, Torey | - |
dc.contributor.googleauthor | Yokoyama, Wallace | - |
dc.relation.code | 2015005577 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | hyunsk15 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.