Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김충현 | - |
dc.date.accessioned | 2017-04-14T05:27:11Z | - |
dc.date.available | 2017-04-14T05:27:11Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, v. 58, NO 2, Page. 159-162 | en_US |
dc.identifier.issn | 2005-3711 | - |
dc.identifier.issn | 1598-7876 | - |
dc.identifier.uri | http://jkns.or.kr/journal/view.php?doi=10.3340/jkns.2015.58.2.159 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26686 | - |
dc.description.abstract | Neurological deficits after brain surgery are not uncommon, and correct and prompt differential diagnosis is essential to initiate appropriate treatment. We describe a patient suffering from loss of consciousness due to hyperammonemia, following valproic acid treatment after surgery for an unruptured cerebral aneurysm. A 57-year-old female patient underwent successful aneurysmal neck clipping to correct an unruptured aneurysm. Her postoperative course was good, and she received anti-epileptic therapy (valproic acid) and a soft diet. Within a few days the patient experienced mental deterioration. Her serum valproic acid reached toxic levels (149.40 mg/L), and serum ammonia was fifteen times the upper normal limit (553 mmol/L; normal range, 9-33 mmol/L). After discontinuation of valproic acid and with conservative treatment, the patient recovered without any complications. Valproate-induced hyperammonemic encephalopathy is an unusual but serious neurosurgical complication, and should not be disregarded as a possible cause of neurological deficits after neurovascular surgery. Early diagnosis is crucial, as discontinuation of valproic acid therapy can prevent serious complications, including death. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN NEUROSURGICAL SOC | en_US |
dc.subject | Hyperammonemia | en_US |
dc.subject | Valproic acid | en_US |
dc.subject | Encephalopathy | en_US |
dc.title | Valproic Acid-Induced Hyperammonemic Encephalopathy as a Cause of Neurologic Deterioration after Unruptured Aneurysm Surgery | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 58 | - |
dc.identifier.doi | 10.3340/jkns.2015.58.2.159 | - |
dc.relation.page | 159-162 | - |
dc.relation.journal | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | - |
dc.contributor.googleauthor | Lee, Sangkook | - |
dc.contributor.googleauthor | Cheong, Jinhwan | - |
dc.contributor.googleauthor | Kim, Choonghyun | - |
dc.contributor.googleauthor | Kim, Jae Min | - |
dc.relation.code | 2015007366 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kch5142 | - |
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