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Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis

Title
Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis
Author
민경환
Keywords
basal-like breast cancer; cancer stem cell; Id1; mammary stem cell; c-Myc
Issue Date
2015-07
Publisher
IMPACT JOURNALS LLC
Citation
ONCOTARGET, v. 6, no. 19, page. 17276-17290
Abstract
Inhibitor of differentiation/DNA binding (Id) 1 is a crucial regulator of mammary development and breast cancer progression. However, its effect on stemness and tumorigenesis in mammary epithelial cells remains undefined. Herein, we demonstrate that Id1 induces mammary tumorigenesis by increasing normal and malignant mammary stem cell (MaSC) activities in transgenic mice. MaSC-enriched basal cell expansion and increased self-renewal and in vivo regenerative capacity of MaSCs are observed in the mammary glands of MMTV-Id1 transgenic mice. Furthermore, MMTV-Id1 mice develop ductal hyperplasia and mammary tumors with highly expressed basal markers. Id1 also increases breast cancer stem cell (CSC) population and activity in human breast cancer lines. Moreover, the effects of Id1 on normal and malignant stem cell activities are mediated by the Wnt/c-Myc pathway. Collectively, these findings provide in vivo genetic evidence of Id1 functions as an oncogene in breast cancer and indicate that Id1 regulates mammary basal stem cells by activating the Wnt/c-Myc pathway, thereby contributing to breast tumor development.
URI
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=3640http://hdl.handle.net/20.500.11754/26639
ISSN
1949-2553
DOI
10.18632/oncotarget.3640
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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