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Optical imaging, biodistribution and toxicity of orally administered quantum dots loaded heparin-deoxycholic acid

Title
Optical imaging, biodistribution and toxicity of orally administered quantum dots loaded heparin-deoxycholic acid
Author
이동윤
Keywords
quantum dot; nonotoxicology; genotoxicity; serum biochemistry; histology
Issue Date
2015-07
Publisher
POLYMER SOC KOREA
Citation
MACROMOLECULAR RESEARCH, v. 23, NO 7, Page. 686-695
Abstract
Quantum dots (QDs) are considered to be one of the most promising optical imaging probes for biological and biomedical applications. However toxicology is the major concern that limits biological application. Though couple of studies have reported focusing on intravenous administration but, in this study, we have observed toxicity of orally administered QDs for the very first time. QDs were loaded into heparin-conjugated deoxycholic acid (QLHD) conjugates. The orally administered Q-LHD nanoparticles were absorbed through bile acid transporter of small intestine. In vitro genotoxicity was observed by chromosomal aberration and comet assay to learn effect of quantum dot in cell mutation. The amount of cadmium content in different organs was also measured by inductive coupled plasma mass spectroscopy. To observe physiological changes, complete blood count, serum biochemistry and organ histology of Q-LHD treated rats were performed accordingly. The in vivo biodistribution results confirm any acute toxicity or significant variations were noted in the rats. Furthermore, oral administration of the Q-LHD nanoparticles does not cause appreciable toxicity, showing no mentionable histological changes of the organs at 45 days after single dose. Though this current study reveals, potential toxicity of Q-LHD nanoparticles is no longer a limiting factor for extending application of QDs in biomedical imaging but long term in vivo genotoxicity studies further required.
URI
http://link.springer.com/article/10.1007/s13233-015-3092-3http://hdl.handle.net/20.500.11754/26591
ISSN
1598-5032; 2092-7673
DOI
10.1007/s13233-015-3092-3
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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