310 0

Clinical effect of white matter network disruption related to amyloid and small vessel disease

Title
Clinical effect of white matter network disruption related to amyloid and small vessel disease
Author
이종민
Keywords
MILD COGNITIVE IMPAIRMENT; SUBCORTICAL VASCULAR DEMENTIA; ALZHEIMERS-DISEASE; CORTICAL THICKNESS; BRAIN; TRACTOGRAPHY; CONNECTIVITY; EFFICIENCY; PRECUNEUS; ATROPHY
Issue Date
2015-07
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
NEUROLOGY, v. 85, NO 1, Page. 63-70
Abstract
Background: We tested our hypothesis that the white matter network might mediate the effect of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition. Methods: We prospectively recruited 232 patients with cognitive impairment. Amyloid was assessed using Pittsburgh compound B-PET. SVD was quantified as white matter hyperintensity volume and lacune number. The regional white matter network connectivity was measured as regional nodal efficiency by applying graph theoretical analysis to diffusion tensor imaging data. We measured cortical thickness and performed neuropsychological tests. Results: SVD burden was associated with decreased nodal efficiency in the bilateral frontal, lateral temporal, lateral parietal, and occipital regions. Path analyses showed that the frontal nodal efficiency mediated the effect of SVD on the frontal atrophy and frontal-executive dysfunction. The temporoparietal nodal efficiency mediated the effect of SVD on the temporoparietal atrophy and memory dysfunction. However, Pittsburgh compound B retention ratio affected cortical atrophy and cognitive impairment without being mediated by nodal efficiency. Conclusions: We suggest that a disrupted white matter network mediates the effect of SVD, but not amyloid, on specific patterns of cortical atrophy and/or cognitive impairment. Therefore, our findings provide insight to better understand how amyloid and SVD burden can give rise to brain atrophy or cognitive impairment in specific patterns.
URI
http://www.neurology.org/content/85/1/63.shorthttp://hdl.handle.net/20.500.11754/26547
ISSN
0028-3878; 1526-632X
DOI
10.1212/WNL.0000000000001705
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE