Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤지희 | - |
dc.date.accessioned | 2017-04-03T04:54:00Z | - |
dc.date.available | 2017-04-03T04:54:00Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | Immune Network, v. 15, NO 3, Page. 161-166 | en_US |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.issn | 2092-6685 | - |
dc.identifier.uri | https://www.immunenetwork.org/search.php?where=aview&id=10.4110/in.2015.15.3.161&code=0078IN&vmode=FULL | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26531 | - |
dc.description.abstract | Early growth response (Egr)-1 is a Cys2-His2-type zincfinger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from Egr1−/− mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between Egr1−/− and WT mice. However, Egr1−/− B cells gave rise to fewer plasma cells than WT B cells. Consistently, Egr1−/− mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells. | en_US |
dc.description.sponsorship | This work was supported by a NRF grant funded by the Ministry of Science, ICT & Future Planning (NRF-2014 R1A2A1A11052070 awarded to J. Youn). | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한면역학회 | en_US |
dc.subject | Egr1 | en_US |
dc.subject | B cells | en_US |
dc.subject | Plasma cells | en_US |
dc.subject | Differentiation | en_US |
dc.subject | Antibody | en_US |
dc.title | Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 15 | - |
dc.identifier.doi | 10.4110/in.2015.15.3.161 | - |
dc.relation.page | 161-166 | - |
dc.relation.journal | Immune Network | - |
dc.contributor.googleauthor | Oh, Yeon-Kyung | - |
dc.contributor.googleauthor | Jang, EunKyeong | - |
dc.contributor.googleauthor | Paik, Doo-Jin | - |
dc.contributor.googleauthor | Youn, Jeehee | - |
dc.relation.code | 2015040999 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jhyoun | - |
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