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Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells

Title
Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells
Author
윤지희
Keywords
Egr1; B cells; Plasma cells; Differentiation; Antibody
Issue Date
2015-07
Publisher
대한면역학회
Citation
Immune Network, v. 15, NO 3, Page. 161-166
Abstract
Early growth response (Egr)-1 is a Cys2-His2-type zincfinger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from Egr1−/− mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between Egr1−/− and WT mice. However, Egr1−/− B cells gave rise to fewer plasma cells than WT B cells. Consistently, Egr1−/− mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells.
URI
https://www.immunenetwork.org/search.php?where=aview&id=10.4110/in.2015.15.3.161&code=0078IN&vmode=FULLhttp://hdl.handle.net/20.500.11754/26531
ISSN
1598-2629; 2092-6685
DOI
10.4110/in.2015.15.3.161
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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