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dc.contributor.author채필석-
dc.date.accessioned2017-03-29T02:10:02Z-
dc.date.available2017-03-29T02:10:02Z-
dc.date.issued2015-07-
dc.identifier.citationCHEMBIOCHEM, v. 16, NO 10, Page. 1454-1459en_US
dc.identifier.issn1439-4227-
dc.identifier.issn1439-7633-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/cbic.201500151/abstract;jsessionid=32AFCFED05EFE6B753B683BF375499B6.f03t03-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26406-
dc.description.abstractDetergents are an absolute requirement for studying the structure of membrane proteins. However, many conventional detergents fail to stabilise denaturation-sensitive membrane proteins, such as eukaryotic proteins and membrane protein complexes. New amphipathic agents with enhanced efficacy in stabilising membrane proteins will be helpful in overcoming the barriers to studying membrane protein structures. We have prepared a number of deoxycholate-based amphiphiles with carbohydrate head groups, designated deoxycholate-based glycosides (DCGs). These DCGs are the hydrophilic variants of previously reported deoxycholate-based N-oxides (DCAOs). Membrane proteins in these agents, particularly the branched diglucoside-bearing amphiphiles DCG-1 and DCG-2, displayed favourable behaviour compared to previously reported parent compounds (DCAOs) and conventional detergents (LDAO and DDM). Given their excellent properties, these agents should have significant potential for membrane protein studies.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (grants number 2008-0061891 and 2013R1A2A2A03067623 to P.S.C. and H.E.B., H.H., M.E. and J.G.), by the Danish Council for Independent Research Sapere Aude program (to C.J.L.) and the UNIK Center for Synthetic Biology (to C.J.L). This work was also supported by European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement no. HEALTH-F4-2007-201924, the EDICT Consortium and the Biotechnology and Biological Sciences Research Council grant BB/K017292/1 (to B.B.). We are grateful to Drs. Chiara Lee and Philip Laible for the gift of GlpG and R. capsulatus superassembly, respectively.en_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.subjectamphiphilesen_US
dc.subjectdeoxycholateen_US
dc.subjectmembrane proteinsen_US
dc.subjectmolecular designen_US
dc.subjectstabilizationen_US
dc.titleDeoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisationen_US
dc.typeArticleen_US
dc.relation.no10-
dc.relation.volume16-
dc.identifier.doi10.1002/cbic.201500151-
dc.relation.page1454-1459-
dc.relation.journalCHEMBIOCHEM-
dc.contributor.googleauthorBae, Hyoung Eun-
dc.contributor.googleauthorGotfryd, Kamil-
dc.contributor.googleauthorThomas, Jennifer-
dc.contributor.googleauthorHussain, Hazrat-
dc.contributor.googleauthorEhsan, Muhammad-
dc.contributor.googleauthorGo, Juyeon-
dc.contributor.googleauthorLoland, Claus J.-
dc.contributor.googleauthorByrne, Bernadette-
dc.contributor.googleauthorChae, Pil Seok-
dc.relation.code2015001809-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidpchae-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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