Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채필석 | - |
dc.date.accessioned | 2017-03-29T02:10:02Z | - |
dc.date.available | 2017-03-29T02:10:02Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | CHEMBIOCHEM, v. 16, NO 10, Page. 1454-1459 | en_US |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.issn | 1439-7633 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/cbic.201500151/abstract;jsessionid=32AFCFED05EFE6B753B683BF375499B6.f03t03 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26406 | - |
dc.description.abstract | Detergents are an absolute requirement for studying the structure of membrane proteins. However, many conventional detergents fail to stabilise denaturation-sensitive membrane proteins, such as eukaryotic proteins and membrane protein complexes. New amphipathic agents with enhanced efficacy in stabilising membrane proteins will be helpful in overcoming the barriers to studying membrane protein structures. We have prepared a number of deoxycholate-based amphiphiles with carbohydrate head groups, designated deoxycholate-based glycosides (DCGs). These DCGs are the hydrophilic variants of previously reported deoxycholate-based N-oxides (DCAOs). Membrane proteins in these agents, particularly the branched diglucoside-bearing amphiphiles DCG-1 and DCG-2, displayed favourable behaviour compared to previously reported parent compounds (DCAOs) and conventional detergents (LDAO and DDM). Given their excellent properties, these agents should have significant potential for membrane protein studies. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (grants number 2008-0061891 and 2013R1A2A2A03067623 to P.S.C. and H.E.B., H.H., M.E. and J.G.), by the Danish Council for Independent Research Sapere Aude program (to C.J.L.) and the UNIK Center for Synthetic Biology (to C.J.L). This work was also supported by European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement no. HEALTH-F4-2007-201924, the EDICT Consortium and the Biotechnology and Biological Sciences Research Council grant BB/K017292/1 (to B.B.). We are grateful to Drs. Chiara Lee and Philip Laible for the gift of GlpG and R. capsulatus superassembly, respectively. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | amphiphiles | en_US |
dc.subject | deoxycholate | en_US |
dc.subject | membrane proteins | en_US |
dc.subject | molecular design | en_US |
dc.subject | stabilization | en_US |
dc.title | Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 16 | - |
dc.identifier.doi | 10.1002/cbic.201500151 | - |
dc.relation.page | 1454-1459 | - |
dc.relation.journal | CHEMBIOCHEM | - |
dc.contributor.googleauthor | Bae, Hyoung Eun | - |
dc.contributor.googleauthor | Gotfryd, Kamil | - |
dc.contributor.googleauthor | Thomas, Jennifer | - |
dc.contributor.googleauthor | Hussain, Hazrat | - |
dc.contributor.googleauthor | Ehsan, Muhammad | - |
dc.contributor.googleauthor | Go, Juyeon | - |
dc.contributor.googleauthor | Loland, Claus J. | - |
dc.contributor.googleauthor | Byrne, Bernadette | - |
dc.contributor.googleauthor | Chae, Pil Seok | - |
dc.relation.code | 2015001809 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | pchae | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.