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Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 최보율 | - |
| dc.date.accessioned | 2017-03-21T00:47:18Z | - |
| dc.date.available | 2017-03-21T00:47:18Z | - |
| dc.date.issued | 2015-07 | - |
| dc.identifier.citation | DIABETES, v. 64, no. 1, Page. 291-298 | en_US |
| dc.identifier.issn | 0012-1797 | - |
| dc.identifier.issn | 1939-327X | - |
| dc.identifier.uri | http://diabetes.diabetesjournals.org/content/early/2014/07/23/db14-0563.short | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11754/26228 | - |
| dc.description.abstract | Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation. | en_US |
| dc.description.sponsorship | This work was supported by grants from Korea Centers for Disease Control and Prevention (4845-301, 4851-302, and 4851-307) and an intramural grant from the Korea National Institute of Health (2012-N73002-00), the Republic of Korea. Y.S.C. acknowledges support from the National Research Foundation of Korea grant funded by the Korean government (Ministry of Education, Science and Technology) (2012R1A2A1A03006155). CLHNS was supported by U.S. National Institutes of Health (NIH) grants DK078150, TW05596, HL085144, and TW008288 and pilot funds from RR20649, ES10126, and DK56350. The authors thank the Office of Population Studies Foundation research and data collection teams and the study participants who generously provided their time for this study. The authors thank Markku Laakso (University of Kuopio, Finland), Michael Boehnke (University of Michigan), Francis Collins (NIH, Bethesda, MD), and the METSIM study investigators for providing access to unpublished data. METSIM data were generated and analyzed with support from the Academy of Finland (contract 124243), the Finnish Heart Foundation, the Finnish Diabetes Foundation, Tekes (contract 1510/31/06), the Commission of the European Community (HEALTH-F2-2007-201681), and NIH grants DK093757, DK072193, DK062370, and 1Z01 HG000024. SBCS was supported by R01CA064277; SMHS by R01CA082729; and GWA studies by R37CA070867, R01CA082729, R01CA124558, R01CA148667, R01CA122364, R01CA122756, and R01CA137013 (all NIH grants), as well as Ingram Professorship and Research Reward funds from the Vanderbilt University School of Medicine. The authors want to thank Regina Courtney (the Vanderbilt University School of Medicine) for DNA preparation and Jing He (the Vanderbilt University School of Medicine) for data processing and analyses. S.O.U. acknowledges a grant from the National 973 Program (2011CB504001), National Natural Science Foundation of China (81170735), and Excellent Young Medical Expert of Shanghai (XYQ2011041). The authors thank all the medical staff of the Shanghai Clinical Center for Diabetes, all the participants and the staff of the BioBank Japan project, and Minoru Iwata, Kazuyuki Tobe (First Department of Internal Medicine, University of Toyama), Kazuki Yasuda, Masato Kasuga (Diabetes Research Center, Research Institute, National Center for Global Health and Medicine), and Hiroshi Hirose (Health Center, Keio University School of Medicine) for the preparation of DNA and clinical information. They also thank the technical staff of the Laboratory for Endocrinology, Metabolism and Kidney diseases at the RIKEN Center for Integrative Medical Sciences for performing SNP genotyping. They thank Hayato Fujita (Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo) for statistical analysis. S.M. acknowledges a grant from the Leading Project of Ministry of Education, Culture, Sports, Science and Technology, Japan. W.J. acknowledges a grant from the National Natural Science Foundation of China (81322010 and 81170735), National 863 Program (2012AA02A509), Shanghai Rising Star Program (12QH1401700), Shanghai Talent Development Grant (2012041), Excellent Young Medical Expert of Shanghai (XYQ2011041), and National Young Top Talent Support Program. The authors would like to acknowledge support from the Hong Kong Foundation for Research and Development in Diabetes, established under the auspices of the Chinese University of Hong Kong, the Hong Kong government Research Grant Committee Central Allocation Scheme (CUHK 1/04C) and Theme-Based Research Scheme (T12-402/13-N), the Innovation and Technology Fund (ITS/088/08 and ITS/487/09FP), a Chinese University Direct Grant, and NIH grant NIH-RFA DK-085545-01 (from the National Institute of Diabetes and Digestive and Kidney Diseases). GenSalt is supported by research grants (U01HL072507, R01HL087263, and R01HL090682) from the NIH National Heart, Lung, and Blood Institute. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | AMER DIABETES ASSOC | en_US |
| dc.subject | TYPE-2 DIABETES RISK | en_US |
| dc.subject | INSULIN-RESISTANCE | en_US |
| dc.subject | GLYCEMIC TRAITS | en_US |
| dc.subject | BETA-CELLS | en_US |
| dc.subject | LOCI | en_US |
| dc.subject | EXPRESSION | en_US |
| dc.subject | SECRETION | en_US |
| dc.subject | MASS | en_US |
| dc.title | Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians | en_US |
| dc.type | Article | en_US |
| dc.relation.volume | 64 | - |
| dc.identifier.doi | 10.2337/db14-0563 | - |
| dc.relation.page | 291-298 | - |
| dc.relation.journal | DIABETES | - |
| dc.contributor.googleauthor | Hwang, Joo-Yeon | - |
| dc.contributor.googleauthor | Sim, Xueling | - |
| dc.contributor.googleauthor | Wu, Ying | - |
| dc.contributor.googleauthor | Liang, Jun | - |
| dc.contributor.googleauthor | Tabara, Yasuharu | - |
| dc.contributor.googleauthor | Hu, Cheng | - |
| dc.contributor.googleauthor | Hara, Kazuo | - |
| dc.contributor.googleauthor | Tam, Claudia H. T. | - |
| dc.contributor.googleauthor | Cai, Qiuyin | - |
| dc.contributor.googleauthor | Choi, Bo Youl | - |
| dc.relation.code | 2015002309 | - |
| dc.sector.campus | S | - |
| dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
| dc.sector.department | DEPARTMENT OF MEDICINE | - |
| dc.identifier.pid | bychoi | - |
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