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dc.contributor.author이창호-
dc.date.accessioned2017-03-16T00:16:35Z-
dc.date.available2017-03-16T00:16:35Z-
dc.date.issued2015-07-
dc.identifier.citationJOURNAL OF GINSENG RESEARCH, v. 39, NO 3, Page. 189-198en_US
dc.identifier.issn1226-8453-
dc.identifier.issn2093-4947-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1226845314001110-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26137-
dc.description.abstractBackground: Antiallergic effect of 20(S)-protopanaxatriol (PPT), an intestinal metabolite of ginseng sa-ponins, was investigated in guinea pig lung mast cells and mouse bone marrow-derived mast cells activated by a specific antigen/antibody reaction. Methods: Increasing concentrations of PPT were pretreated 5 min prior to antigen stimulation, and various inflammatory mediator releases and their relevant cellular signaling events were measured in those cells. Results: PPT dose-dependently reduced the release of histamine and leukotrienes in both types of mast cells. Especially, in activated bone marrow-derived mast cells, PPT inhibited the expression of Syk protein, cytokine mRNA, cyclooxygenase-1/2, and phospholipase A(2) (PLA(2)), as well as the activities of various protein kinase C isoforms, mitogen-activated protein kinases, PLA(2), and transcription factors (nuclear factor-kappa B and activator protein-1). Conclusion: PPT reduces the release of inflammatory mediators via inhibiting multiple cellular signaling pathways comprising the Ca2+ influx, protein kinase C, and PLA(2), which are propagated by Syk activation upon allergic stimulation of mast cells. Copyright (C) 2014, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the grant from the Korean Society of Ginseng funded Korea Ginseng Corp (2002) for C.H.L. and from the Samsung Biomedical Research Institute, Sungkynkwan University School of Medicine for J.Y.R.en_US
dc.language.isoenen_US
dc.publisherKOREAN SOC GINSENGen_US
dc.subject20(S)-protopanaxatriolen_US
dc.subjectinflammatory mediatorsen_US
dc.subjectmast cellsen_US
dc.subjectPanax ginsengen_US
dc.title20(S)-Protopanaxatriol inhibits release of inflammatory mediators in immunoglobulin E-mediated mast cell activationen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume39-
dc.identifier.doi10.1016/j.jgr.2014.11.001-
dc.relation.page189-198-
dc.relation.journalJOURNAL OF GINSENG RESEARCH-
dc.contributor.googleauthorKim, Dae Yong-
dc.contributor.googleauthorRo, Jai Youl-
dc.contributor.googleauthorLee, Chang Ho-
dc.relation.code2015011537-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjennysue-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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