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dc.contributor.author김혁-
dc.date.accessioned2017-03-14T02:23:39Z-
dc.date.available2017-03-14T02:23:39Z-
dc.date.issued2015-07-
dc.identifier.citationMOLECULAR AND CELLULAR ENDOCRINOLOGY, v. 414, NO C, Page. 64-72en_US
dc.identifier.issn0303-7207-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S030372071530023X-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/26092-
dc.description.abstractEffective treatment of diabetic neuropathy (DN) remains unsolved. We serendipitously observed dramatic relief of pain in several patients with painful DN receiving granulocyte-colony stimulating factor (G-CSF). The aim of this study was to determine if G-CSF could treat DN in an animal model and to ascertain its mechanism of action. In a rodent model of DN, G-CSF dramatically recovered nerve function, retarded histological nerve changes and increased the expression of neurotrophic factors within nerve. A sex-mismatched bone marrow transplantation (BMT) study revealed that G-CSF treatment increased the abundance of bone marrow (BM)-derived cells in nerves damaged by DN. However, we did not observe evidence of transdifferentiation or cell fusion of BM-derived cells. The beneficial effects of G-CSF were dependent on the integrity of BM. In conclusion, G-CSF produced a therapeutic effect in a rodent model of DN, which was attributed, at least in part, to the actions of BM-derived cells. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by a Medical Research Center grant (2011-0028261) funded by the National Research Foundation of Korea (NRF) of the Korea government (MSIP); a California Institute for Regenerative Medicine (CIRM) Comprehensive Research Grant [RC1-00125-1]; NIH Grants.en_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectGranulocyte-colony stimulating factoren_US
dc.subjectBone marrow-derived cellsen_US
dc.titleGranulocyte-colony stimulating factor as a treatment for diabetic neuropathy in raten_US
dc.typeArticleen_US
dc.relation.noC-
dc.relation.volume414-
dc.identifier.doi10.1016/j.mce.2015.07.014-
dc.relation.page64-72-
dc.relation.journalMOLECULAR AND CELLULAR ENDOCRINOLOGY-
dc.contributor.googleauthorKim, Kyung-Soo-
dc.contributor.googleauthorSong, Yi-Sun-
dc.contributor.googleauthorJin, Jiyong-
dc.contributor.googleauthorJoe, Jun-Ho-
dc.contributor.googleauthorSo, Byung-Im-
dc.contributor.googleauthorPark, Jun-Young-
dc.contributor.googleauthorFang, Cheng-Hu-
dc.contributor.googleauthorKim, Mi Jung-
dc.contributor.googleauthorCho, Youl-Hee-
dc.contributor.googleauthorKim, Hyuck-
dc.relation.code2015002239-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkhkim-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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