Selective preconcentration and online collection of charged molecules using ion concentration polarization
- Title
- Selective preconcentration and online collection of charged molecules using ion concentration polarization
- Author
- Hong, Jong Wook
- Keywords
- TOTAL ANALYSIS SYSTEMS; MULTIPHYSICS SIMULATION; SAMPLE STACKING; CHANNEL DEVICES; ACTIVITY ASSAY; ELECTROPHORESIS; ENHANCEMENT; LAYER
- Issue Date
- 2015-07
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC ADVANCES, v. 5, NO 81, Page. 66178-66184
- Abstract
- A multilayer micro/nanofluidic device was presented for the selective preconcentration and online collection of charged molecules with different physicochemical properties based on ion concentration polarization phenomena. With a balance of electroosmotic drag force and electrophoretic force on the molecules, a sample mixture of sulforhodamine B and Alexa Fluor 488 could be highly preconcentrated and separated simultaneously. A repeated microchamber structure was employed to capture each dye at a desirable position. For subsequent on-chip or off-chip application, pneumatic microvalves were integrated and selectively collected the target dyes with cyclic valve operations. Using the integrated system, Alexa Fluor 488 was solely collected (with a separation resolution of 1.75) out of the mixture at a 30-fold preconcentration ratio. This integrated device would be a key component for lab on a chip applications.
- URI
- http://pubs.rsc.org/is/content/articlehtml/2015/ra/c5ra12639hhttp://hdl.handle.net/20.500.11754/26047
- ISSN
- 2046-2069
- DOI
- 10.1039/c5ra12639h
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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