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Selective preconcentration and online collection of charged molecules using ion concentration polarization

Title
Selective preconcentration and online collection of charged molecules using ion concentration polarization
Author
Hong, Jong Wook
Keywords
TOTAL ANALYSIS SYSTEMS; MULTIPHYSICS SIMULATION; SAMPLE STACKING; CHANNEL DEVICES; ACTIVITY ASSAY; ELECTROPHORESIS; ENHANCEMENT; LAYER
Issue Date
2015-07
Publisher
ROYAL SOC CHEMISTRY
Citation
RSC ADVANCES, v. 5, NO 81, Page. 66178-66184
Abstract
A multilayer micro/nanofluidic device was presented for the selective preconcentration and online collection of charged molecules with different physicochemical properties based on ion concentration polarization phenomena. With a balance of electroosmotic drag force and electrophoretic force on the molecules, a sample mixture of sulforhodamine B and Alexa Fluor 488 could be highly preconcentrated and separated simultaneously. A repeated microchamber structure was employed to capture each dye at a desirable position. For subsequent on-chip or off-chip application, pneumatic microvalves were integrated and selectively collected the target dyes with cyclic valve operations. Using the integrated system, Alexa Fluor 488 was solely collected (with a separation resolution of 1.75) out of the mixture at a 30-fold preconcentration ratio. This integrated device would be a key component for lab on a chip applications.
URI
http://pubs.rsc.org/is/content/articlehtml/2015/ra/c5ra12639hhttp://hdl.handle.net/20.500.11754/26047
ISSN
2046-2069
DOI
10.1039/c5ra12639h
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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