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dc.contributor.author김진웅-
dc.date.accessioned2017-03-03T02:41:51Z-
dc.date.available2017-03-03T02:41:51Z-
dc.date.issued2015-06-
dc.identifier.citationMACROMOLECULAR CHEMISTRY AND PHYSICS, v. 216, NO 11, Page. 1161-1170en_US
dc.identifier.issn1022-1352-
dc.identifier.issn1521-3935-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/macp.201500047/full-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25816-
dc.description.abstractThe major limitations of nanocarriers for drug delivery are the poor biocompatibility and low stability that may induce the unintended burst release of loaded drugs during blood circulation. To overcome these limitations, a photocrosslinkable amphiphilic block copolymer consisting of hydrophobic poly(epsilon-caprolactone) (PCL) block and a hydrophilic hyperbranched polyglycerol (hbPG) block with improved biocompatibility and stability for drug delivery is developed. They are readily prepared via UV-triggered chemical crosslinking with 4-hydroxycinnamic acid (CA) modification in the hbPG block. The photocrosslinked hbPG-b-PCL-CA nanoparticles are spherical and the size of nanoparticles is increased to 60 30 nm. Photocrosslinked hbPG-b-PCL-CA nanoparticles exhibit significantly high stability in a physiological buffer and the loaded drug in sustained manner. In addition, photocrosslinked hbPG-b-PCL-CA nanoparticles show good biocompatibility in vitro and in vivo. These data imply the promising potential of photocrosslinked hbPG-b-PCL-CA nanoparticles as nanocarriers for drug delivery.en_US
dc.description.sponsorshipS.-W.K. and U.J. contributed equally to this work. U.J. thanks the support from the MSIP(Ministry of Science, ICT and Future Planning) under the IT Consilience Creative Program" (NIPA-2013-H0203-13-1001). This work was supported by a National Research Foundation (NRF) grant funded by the Korean Government (MEST) through the Active Polymer Center Pattern Integration (Grant No. R11-2007-050-01004-0). All animals were purchased (OrientBio, Seongnam-si, Gyeonggi-do, Korea) and the experiments were performed in compliance with the Institutional Animal Care and Use Committee of Korea Institute of Toxicology (IACUC #14-1-0163) and the Guidelines for the Care and Use of Laboratory Animals of the National Research Council.en_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.subjectamphiphilic bloc copolymeren_US
dc.subjectbiodegradable micelleen_US
dc.subjectdrug delivery systemen_US
dc.subjecthyperbranched polyglycerolen_US
dc.subjectsustained releaseen_US
dc.titlePhotocrosslinkable Poly(epsilon-caprolactone)-b-Hyperbranched Polyglycerol (PCL-b-hbPG) with Improved Biocompatibility and Stability for Drug Deliveryen_US
dc.typeArticleen_US
dc.relation.no11-
dc.relation.volume216-
dc.identifier.doi10.1002/macp.201500047-
dc.relation.page1161-1170-
dc.relation.journalMACROMOLECULAR CHEMISTRY AND PHYSICS-
dc.contributor.googleauthorKim, Yong-Jin-
dc.contributor.googleauthorKim, Bongsoo-
dc.contributor.googleauthorHyun, Dong Choon-
dc.contributor.googleauthorKim, Jin Woong-
dc.contributor.googleauthorShim, Hye-Eun-
dc.contributor.googleauthorKang, Sun-Woong-
dc.contributor.googleauthorJeong, Unyong-
dc.relation.code2015000705-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidkjwoong-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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