Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박유신 | - |
dc.date.accessioned | 2017-03-03T02:28:57Z | - |
dc.date.available | 2017-03-03T02:28:57Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | ANNALS OF NUTRITION AND METABOLISM, v. 66, NO 2-3, Page. 141-148 | en_US |
dc.identifier.issn | 0250-6807 | - |
dc.identifier.issn | 1421-9697 | - |
dc.identifier.uri | http://www.karger.com/Article/Abstract/377640 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/25814 | - |
dc.description.abstract | Background: Controversy over the efficacy of n-3 polyunsaturated fatty acids (PUFAs) in depression continues to this day. The present study investigated the hypothesis that n-3 PUFA supplementation reduces depressive symptoms in Korean patients with major depressive disorder. Methods: In a randomized, double-blind, placebo-controlled, 12-week, parallel-group trial, 35 patients with Center for Epidemiological Studies Depression Scale Korean version (CES-D-K) scores >= 25 and depression confirmed by a psychiatrist were assigned to take either 3 capsules of n-3 PUFAs (1,140 mg of EPA + 600 mg of DHA; n = 18) or placebo (olive oil + safflower oil; n = 17). Results: Supplementation with n-3 PUFAs significantly reduced Clinical Global Impression Improvement (CGI-I) scores as compared with intake of placebo using intention-to-treat analysis with last-observation-carried-forward after adjusting for energy, fat, and fish intake. However, the CES-D-K, Hamilton Depression Rating Scale-17, and Clinical Global Impression Scale scores did not significantly differ between the n-3 PUFA and placebo groups. After supplementation with n-3 PUFAs, the erythrocyte levels of n-3 PUFAs were significantly increased, but n-6 PUFA levels were decreased. Conclusions: n-3 PUFAs demonstrated an advantage over placebo that did not reach clinical significance, although CGI-I score was significantly decreased in the n-3 PUFA group as compared with the placebo group. (C) 2015 S. Karger AG, Basel | en_US |
dc.description.sponsorship | This work was supported by the Korea Research Foundation (2012R1A2040553) funded by the Korean Government. This study was registered with the Clinical Research Information Service (KCT0001206). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Korean | en_US |
dc.subject | Major depressive disorder | en_US |
dc.subject | n-3 polyunsaturated fatty acid | en_US |
dc.subject | Randomized placebo-controlled trial | en_US |
dc.title | Supplementation of n-3 Polyunsaturated Fatty Acids for Major Depressive Disorder: A Randomized, Double-Blind, 12-Week, Placebo-Controlled Trial in Korea | en_US |
dc.type | Article | en_US |
dc.relation.no | 2-3 | - |
dc.relation.volume | 66 | - |
dc.identifier.doi | 10.1159/000377640 | - |
dc.relation.page | 141-148 | - |
dc.relation.journal | ANNALS OF NUTRITION AND METABOLISM | - |
dc.contributor.googleauthor | Park, Yongsoon | - |
dc.contributor.googleauthor | Park, Yoo-Sin | - |
dc.contributor.googleauthor | Kim, Seok Hyeon | - |
dc.contributor.googleauthor | Oh, Dong Hoon | - |
dc.contributor.googleauthor | Park, Yong-Chon | - |
dc.relation.code | 2015002979 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | hidocys | - |
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