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dc.contributor.author배상철-
dc.date.accessioned2017-03-02T05:45:04Z-
dc.date.available2017-03-02T05:45:04Z-
dc.date.issued2015-06-
dc.identifier.citationRHEUMATOLOGY INTERNATIONAL, v. 35, NO 6, Page. 953-961en_US
dc.identifier.issn0172-8172-
dc.identifier.issn1437-160X-
dc.identifier.urihttp://link.springer.com/article/10.1007/s00296-014-3155-3-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25764-
dc.description.abstractThe aim of this study was to determine whether the functional HLA-G 14 bp insertion (I)/deletion (D) and +3142 G/C polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the HLA-G 14 bp I/D, and +3142 G/C polymorphisms and SLE or RA using; (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) additive model. A total of 14 comparison studies from 11 articles met our inclusion criteria, comprising eight on SLE (1,284 patients and 1,885 controls) and four on RA (820 patients and 772 controls), and three studies investigated response to methotrexate (MTX) in RA according to the HLA-G 14 bp I/D polymorphisms (249 responders and 205 nonresponders). Meta-analysis revealed an association between the II + ID genotype of the HLA-G 14 bp I/D polymorphism in overall group (OR = 1.205, 95 % CI = 1.036-1.403, P = 0.016). Ethnicity-specific meta-analysis showed no association between the II + ID genotype and SLE in the South American, European, and Asian population. Meta-analysis revealed a significant association between SLE and the HLA-G +3142 G allele in all study subjects (OR = 1.367, 95 % CI = 1.158-1.613, P = 2.2 x 10(-5)) and in the South American group (OR = 1.531, 95 % CI = 1.242-1.888, P = 6.7 x 10(-5)). However, no association between HLA-G 14 bp I/D, and +3142 G/C polymorphisms and RA was found (OR for HLA-G I allele = 1.013, 95 % CI = 0.879-1.167, P = 0.859; OR for +3142 G allele = 0.980, 95 % CI = 0.742-1.294, P = 0.888). Furthermore, HLA-G 14 bp I/D polymorphism was not found to be associated with response to MTX in RA. This meta-analysis demonstrates that the HLA-G 14 bp I/D polymorphism is associated with susceptibility to SLE, and HLA-G +3142 G/C polymorphisms are associated with susceptibility to SLE in South Americans.en_US
dc.description.sponsorshipThis study was supported in part by a Grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).en_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.subjectSystemic lupus erythematosusen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectHLA-Gen_US
dc.subjectPolymorphismen_US
dc.subjectMeta-analysisen_US
dc.titleMeta-analysis of associations between functional HLA-G polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritisen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume35-
dc.identifier.doi10.1007/s00296-014-3155-3-
dc.relation.page953-961-
dc.relation.journalRHEUMATOLOGY INTERNATIONAL-
dc.contributor.googleauthorLee, Young Ho-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.contributor.googleauthorSong, Gwan Gyu-
dc.relation.code2015003449-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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