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dc.contributor.author지용배-
dc.date.accessioned2017-02-27T04:58:37Z-
dc.date.available2017-02-27T04:58:37Z-
dc.date.issued2015-06-
dc.identifier.citationTUMOR BIOLOGY, v. 36, NO 6, Page. 4387-4396en_US
dc.identifier.issn1010-4283-
dc.identifier.issn1423-0380-
dc.identifier.urihttp://link.springer.com/article/10.1007/s13277-015-3078-y-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25701-
dc.description.abstractAlcohol consumption is one of the major risk factors for head and neck squamous cell carcinoma (HNSCC), and the alcohol dehydrogenase (ADH) family proteins are key enzymes in ethanol metabolism. We examined the associations between single nucleotide polymorphisms (SNPs) of ADH1B and ADH1C and the risk of HNSCC. We analyzed six SNPS of ADH1B, namely -992C ˃ G, -957C ˃ A, +3170A ˃ G, +3377G ˃ T, +3491G ˃ A, and +13543A ˃ G, and five SNPs of ADH1C, namely -1064C ˃ T, -325G ˃ C, +5702A ˃ G, +7462T ˃ C, and +13044A ˃ G, in 260 Korean HNSCC patients and 330 controls, using single base extension and the TaqMan assay. The odds ratios (ORs) and 95 % confidence intervals (95 % CIs) of the CG and GG genotypes of ADH1B -992C ˃ G, the AA genotype of -957C ˃ A, the GG genotype of +3170A ˃ G, the GA genotype of +3491G ˃ A, and +13543A ˃ G were 0.51 (0.32-0.82), 0.63 (0.42-0.94), 1.84 (1.13-2.99), 1.77 (1.15-2.73), 2.34 (1.44-3.79), and 2.21 (1.23-3.95), respectively. The ORs of ADH1C +13044A ˃ G were 1.94 (1.01-3.71) and 1.97 (1.05-3.71) in the dominant and co-dominant models, respectively. The ORs of the GC genotype of ADH1C -325G ˃ C and the AG genotype of +5702A ˃ G were 2.52 (1.51-4.21) and 2.43 (1.36-4.32), respectively. ADH1B +3170A ˃ G and ADH1C +13044A ˃ G were in strong linkage disequilibrium with the other SNPs of ADH1B and ADH1C, respectively. There were gene-environment interactions between ADH1B +3170A ˃ G and ADH1C +13044A ˃ G and alcohol consumption and smoking. ADH1B +3170A ˃ G and ADH1C +13044A ˃ G SNPs are associated with an increased risk of HNSCC, and they could be used as biomarkers for the high-risk group of HNSCC in Koreans.en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectPolymorphismen_US
dc.subjectSNPen_US
dc.subjectADH1Ben_US
dc.subjectADH1Cen_US
dc.subjectHead and neck canceren_US
dc.titleAssociation between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinomaen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume36-
dc.identifier.doi10.1007/s13277-015-3078-y-
dc.relation.page4387-4396-
dc.relation.journalTUMOR BIOLOGY-
dc.contributor.googleauthorJi, Yong Bae-
dc.contributor.googleauthorLee, Seung Hwan-
dc.contributor.googleauthorKim, Kyung Rae-
dc.contributor.googleauthorPark, Chul Won-
dc.contributor.googleauthorSong, Chang Myeon-
dc.contributor.googleauthorPark, Byung Lae-
dc.contributor.googleauthorShin, Hyoung Doo-
dc.contributor.googleauthorTae, Kyung-
dc.relation.code2015001496-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjyb20000-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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