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miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas

Title
miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas
Author
최동호
Keywords
ampulla of Vater; pancreatic cancer; gene expression
Issue Date
2015-06
Publisher
ZHEJIANG UNIV SCH MEDICINE
Citation
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, v. 14, NO 3, Page. 325-329
Abstract
Distinguishing arnpullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.
URI
http://www.sciencedirect.com/science/article/pii/S149938721560368Xhttp://hdl.handle.net/20.500.11754/25569
ISSN
1499-3872
DOI
10.1016/S1499-3872(15)60368-X
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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