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dc.contributor.author최동호-
dc.date.accessioned2017-02-21T04:22:20Z-
dc.date.available2017-02-21T04:22:20Z-
dc.date.issued2015-06-
dc.identifier.citationHEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, v. 14, NO 3, Page. 325-329en_US
dc.identifier.issn1499-3872-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S149938721560368X-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25569-
dc.description.abstractDistinguishing arnpullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.en_US
dc.description.sponsorshipThe study was supported by grants from the Proteogenomic Research Program through the National Research Foundation of Korea; and the Converging Research Center Program (2013K000429) funded by the Korean Ministry of Science, ICT, and Future Planning.en_US
dc.language.isoenen_US
dc.publisherZHEJIANG UNIV SCH MEDICINEen_US
dc.subjectampulla of Vateren_US
dc.subjectpancreatic canceren_US
dc.subjectgene expressionen_US
dc.titlemiR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomasen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume14-
dc.identifier.doi10.1016/S1499-3872(15)60368-X-
dc.relation.page325-329-
dc.relation.journalHEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL-
dc.contributor.googleauthorChoi, Dong Ho-
dc.contributor.googleauthorPark, Sang Jae-
dc.contributor.googleauthorKim, Hark Kyun-
dc.relation.code2015008911-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidcrane87-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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