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Reduction of Nfia gene expression and subsequent target genes by binge alcohol in the fetal brain

Title
Reduction of Nfia gene expression and subsequent target genes by binge alcohol in the fetal brain
Author
채영규
Keywords
Maternal alcohol consumption; Microarray analysis; FASD; Hippocampus
Issue Date
2015-06
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v. 598, Page. 73-78
Abstract
The objective of the present study was to investigate the changes in gene expression in the fetal brain (forebrain and hippocampus) caused by maternal binge alcohol consumption. Pregnant C57BL/6J mice were treated intragastrically with distilled phosphate-buffered saline (PBS) or ethanol (2.9 g/kg) from embryonic day (ED) 8-12. Microarray analysis revealed that a significant number of genes were altered at ED 18 in the developing brain. Specifically, in hippocampus, nuclear factor one alpha (Nfia) and three N-methyl-D-aspartate (Nmda) receptors (Nmdar1, Nmdar2b, and Nmdar2d) were down-regulated. The transcription factor Nfia controls gliogenesis, cell proliferation and Nmda-induced neuronal survival by regulating the expression of target genes. Some of the Nfia-target gene (Aldh1a, Folh1, Gjb6, Fgf1, Neurod1, Sept4, and Ntsr2) expressions were also altered as expected. These results suggest that the altered expression of Nfia and Nmda receptors may be associated with the etiology of fetal alcohol syndrome (FAS). The data presented in this report will contribute to the understanding of the molecular mechanisms associated with the effects of alcohol in FASD individuals. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0304394015003651http://hdl.handle.net/20.500.11754/25199
ISSN
0304-3940; 1872-7972
DOI
10.1016/j.neulet.2015.05.016
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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