Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고인송 | - |
dc.date.accessioned | 2017-01-16T04:31:20Z | - |
dc.date.available | 2017-01-16T04:31:20Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | MOLECULAR MEDICINE REPORTS, v. 12, NO 1, Page. 1568-1578 | en_US |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.issn | 1791-3004 | - |
dc.identifier.uri | https://www.spandidos-publications.com/10.3892/mmr.2015.3544 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/25159 | - |
dc.description.abstract | Tuberculosis (TB) is an infectious disease caused by mycobacterium, which most commonly affects the lungs. The adaptive immune response in Mycobacterium tuberculosis is predominantly mediated by the interferon- (IFN-) signaling pathway, which is regulated by IFN- receptors (IFNGR). IFN- activates the transcription of a number of genes that are important in immune responses, thus the appropriate function of IFNGR appears to be important in host defense against mycobacteria. In the present study, 22 genetic variants in IFNGR1 and IFNGR2 were genotyped in 673 patients and 592 normal controls to investigate the association between IFNGR1 and IFNGR2 polymorphisms and the risk of TB. Statistical analyses revealed that four genetic variants in IFNGR1, rs9376269, rs9376268, rs9376267 and rs56251346 were marginally associated with the risk of TB (P=0.02-0.04), while other single nucleotide polymorphisms in IFNGR1 and IFNGR2 did not exhibit any associations. However, the significance of the four genetic variants rs9376269, rs9376268, rs9376267 and rs56251346 was eliminated following a multiple testing correction of the data (P˃0.05). The present results revealed that certain genetic variants in IFNGR genes may be associated with TB development, which may be useful preliminary data for future investigation. | en_US |
dc.description.sponsorship | The present study was supported by the Korean Science and Engineering Foundation funded by the Korean government (grant no. NRF-2011-0021659). The DNA samples were generously provided by Soonchunhyang University, Bucheon Hospital Biobank and a member of the National Biobank of Korea, supported by the Ministry of Health, Welfare and Family Affairs, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.subject | single nucleotide polymorphism | en_US |
dc.subject | interferon- receptor 1 | en_US |
dc.subject | interferon- receptor 2 | en_US |
dc.subject | tuberculosis | en_US |
dc.title | Association study of polymorphisms in interferon-gamma receptor genes with the risk of pulmonary tuberculosis | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 12 | - |
dc.identifier.doi | 10.3892/mmr.2015.3544 | - |
dc.relation.page | 1568-1578 | - |
dc.relation.journal | MOLECULAR MEDICINE REPORTS | - |
dc.contributor.googleauthor | Shin, Joong-Gon | - |
dc.contributor.googleauthor | Park, Byung Lae | - |
dc.contributor.googleauthor | Kim, Lyoung Hyo | - |
dc.contributor.googleauthor | Namgoong, Suhg | - |
dc.contributor.googleauthor | Kim, Ji On | - |
dc.contributor.googleauthor | Chang, Hun Soo | - |
dc.contributor.googleauthor | Park, Jong Sook | - |
dc.contributor.googleauthor | Jang, An Soo | - |
dc.contributor.googleauthor | Park, Sung Woo | - |
dc.contributor.googleauthor | Koh, Insong | - |
dc.relation.code | 2015009761 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | insong | - |
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