266 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author고인송-
dc.date.accessioned2017-01-16T04:23:10Z-
dc.date.available2017-01-16T04:23:10Z-
dc.date.issued2015-06-
dc.identifier.citationINFECTION GENETICS AND EVOLUTION, v. 33, Page. 72-76en_US
dc.identifier.issn1567-1348-
dc.identifier.issn1567-7257-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1567134815001380-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/25157-
dc.description.abstractA recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population. We attempted to replicate the associations between the two SNP loci and the risk of HCC in a Korean population. The rs7574865 in STAT4 and rs9275319 in HLA-DQ were genotyped in a total of 3838 Korean subjects composed of 287 HBV-related hepatocellular carcinoma patients, 671 chronic hepatitis B virus (CHB) patients, and 2880 population controls using TaqMan genotyping assay. Gene expression was measured by microarray. A logistic regression analysis revealed that rs7574865 in STAT4 and rs9275319 in HLA-DQ were associated with the risk of CHB (OR = 1.25, P = 0.0002 and OR = 1.57, P = 1.44 x 10(-10), respectively). However, these loci were no association with the risk of HBV-related HCC among CHB patients. In the gene expression analyses, although no significant differences in mRNA expression of nearby genes according to genotypes were detected, a significantly decreased mRNA expression in HCC subjects was observed in STAT4, HLA-DQA1, and HLA-DQB1. Although the genetic effects of two HCC susceptibility loci were not replicated, the two loci were found to exert susceptibility effects on the risk of CHB in a Korean population. In addition, the decreased mRNA expression of STAT4, HLA-DQA1, and HLA-DQB1 in HCC tissue might provide a clue to understanding their role in the progression to HCC. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectChronic hepatitis B virusen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectHLA-DQen_US
dc.subjectSTAT4en_US
dc.titleReplication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean populationen_US
dc.typeArticleen_US
dc.relation.volume33-
dc.identifier.doi10.1016/j.meegid.2015.04.013-
dc.relation.page72-76-
dc.relation.journalINFECTION GENETICS AND EVOLUTION-
dc.contributor.googleauthorKim, Lyoung Hyo-
dc.contributor.googleauthorCheong, Hyun Sub-
dc.contributor.googleauthorNamgoong, Suhg-
dc.contributor.googleauthorKim, Ji On-
dc.contributor.googleauthorKim, Jeong-Hyun-
dc.contributor.googleauthorPark, Byung Lae-
dc.contributor.googleauthorCho, Sung Won-
dc.contributor.googleauthorPark, Neung Hwa-
dc.contributor.googleauthorCheong, Jae Youn-
dc.contributor.googleauthorKoh, InSong-
dc.contributor.googleauthorShin, Hyoung Doo-
dc.contributor.googleauthorKim, Yoon-Jun-
dc.relation.code2015011341-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidinsong-
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE