Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 고인송 | - |
dc.date.accessioned | 2017-01-16T04:23:10Z | - |
dc.date.available | 2017-01-16T04:23:10Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | INFECTION GENETICS AND EVOLUTION, v. 33, Page. 72-76 | en_US |
dc.identifier.issn | 1567-1348 | - |
dc.identifier.issn | 1567-7257 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1567134815001380 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/25157 | - |
dc.description.abstract | A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population. We attempted to replicate the associations between the two SNP loci and the risk of HCC in a Korean population. The rs7574865 in STAT4 and rs9275319 in HLA-DQ were genotyped in a total of 3838 Korean subjects composed of 287 HBV-related hepatocellular carcinoma patients, 671 chronic hepatitis B virus (CHB) patients, and 2880 population controls using TaqMan genotyping assay. Gene expression was measured by microarray. A logistic regression analysis revealed that rs7574865 in STAT4 and rs9275319 in HLA-DQ were associated with the risk of CHB (OR = 1.25, P = 0.0002 and OR = 1.57, P = 1.44 x 10(-10), respectively). However, these loci were no association with the risk of HBV-related HCC among CHB patients. In the gene expression analyses, although no significant differences in mRNA expression of nearby genes according to genotypes were detected, a significantly decreased mRNA expression in HCC subjects was observed in STAT4, HLA-DQA1, and HLA-DQB1. Although the genetic effects of two HCC susceptibility loci were not replicated, the two loci were found to exert susceptibility effects on the risk of CHB in a Korean population. In addition, the decreased mRNA expression of STAT4, HLA-DQA1, and HLA-DQB1 in HCC tissue might provide a clue to understanding their role in the progression to HCC. (C) 2015 Elsevier B.V. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Chronic hepatitis B virus | en_US |
dc.subject | Hepatocellular carcinoma | en_US |
dc.subject | HLA-DQ | en_US |
dc.subject | STAT4 | en_US |
dc.title | Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean population | en_US |
dc.type | Article | en_US |
dc.relation.volume | 33 | - |
dc.identifier.doi | 10.1016/j.meegid.2015.04.013 | - |
dc.relation.page | 72-76 | - |
dc.relation.journal | INFECTION GENETICS AND EVOLUTION | - |
dc.contributor.googleauthor | Kim, Lyoung Hyo | - |
dc.contributor.googleauthor | Cheong, Hyun Sub | - |
dc.contributor.googleauthor | Namgoong, Suhg | - |
dc.contributor.googleauthor | Kim, Ji On | - |
dc.contributor.googleauthor | Kim, Jeong-Hyun | - |
dc.contributor.googleauthor | Park, Byung Lae | - |
dc.contributor.googleauthor | Cho, Sung Won | - |
dc.contributor.googleauthor | Park, Neung Hwa | - |
dc.contributor.googleauthor | Cheong, Jae Youn | - |
dc.contributor.googleauthor | Koh, InSong | - |
dc.contributor.googleauthor | Shin, Hyoung Doo | - |
dc.contributor.googleauthor | Kim, Yoon-Jun | - |
dc.relation.code | 2015011341 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | insong | - |
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