Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김계성 | - |
dc.date.accessioned | 2017-01-10T01:01:00Z | - |
dc.date.available | 2017-01-10T01:01:00Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | International Journal of Stem Cells, v. 8, Page. 18-23 | en_US |
dc.identifier.issn | 2005-3606 | - |
dc.identifier.issn | 2005-5447 | - |
dc.identifier.uri | http://www.ijstemcell.com/journal/view.html?doi=10.15283/ijsc.2015.8.1.18 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/25003 | - |
dc.description.abstract | Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment. | en_US |
dc.description.sponsorship | This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2013K1A3A1A20046548) and by a grant of the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A120262). This work was supported by grants to J.J from the International S&T Cooperation Program of the Ministry of Science and Technology of China (2014DFG32790). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Society for Stem Cell Research | en_US |
dc.subject | Estrogen | en_US |
dc.subject | Hematopoiesis | en_US |
dc.subject | Niche | en_US |
dc.subject | Stem cells | en_US |
dc.title | Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen | en_US |
dc.type | Article | en_US |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.15283/ijsc.2015.8.1.18 | - |
dc.relation.page | 18-23 | - |
dc.relation.journal | International Journal of Stem Cells | - |
dc.contributor.googleauthor | Heo, Hye-Ryeon | - |
dc.contributor.googleauthor | Chen, Li | - |
dc.contributor.googleauthor | An, Borim | - |
dc.contributor.googleauthor | Kim, Kye-Seong | - |
dc.contributor.googleauthor | Ji, Junfeng | - |
dc.contributor.googleauthor | Hong, Seok-Ho | - |
dc.relation.code | 2015027340 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | ks66kim | - |
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