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Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen

Title
Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen
Author
김계성
Keywords
Estrogen; Hematopoiesis; Niche; Stem cells
Issue Date
2015-05
Publisher
Korean Society for Stem Cell Research
Citation
International Journal of Stem Cells, v. 8, Page. 18-23
Abstract
Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.
URI
http://www.ijstemcell.com/journal/view.html?doi=10.15283/ijsc.2015.8.1.18http://hdl.handle.net/20.500.11754/25003
ISSN
2005-3606; 2005-5447
DOI
10.15283/ijsc.2015.8.1.18
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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