Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen
- Title
- Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen
- Author
- 김계성
- Keywords
- Estrogen; Hematopoiesis; Niche; Stem cells
- Issue Date
- 2015-05
- Publisher
- Korean Society for Stem Cell Research
- Citation
- International Journal of Stem Cells, v. 8, Page. 18-23
- Abstract
- Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.
- URI
- http://www.ijstemcell.com/journal/view.html?doi=10.15283/ijsc.2015.8.1.18http://hdl.handle.net/20.500.11754/25003
- ISSN
- 2005-3606; 2005-5447
- DOI
- 10.15283/ijsc.2015.8.1.18
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- Hormonal Regulation of Hematopoietic Stem Cells and Their Niche A Focus on Estrogen.pdfDownload
- Export
- RIS (EndNote)
- XLS (Excel)
- XML