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Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients

Title
Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients
Author
이종민
Keywords
Cognition; Amyloid; Pittsburgh compound B; Atrophy; Cortical thickness; Hippocampus; Path analysis; Cerebrovascular disease
Issue Date
2015-05
Publisher
ELSEVIER SCIENCE INC
Citation
ALZHEIMERS & DEMENTIA, v. 11, NO 5, Page. 494-503
Abstract
Background: We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition. Methods: Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effects of these markers on cognition. Results: PiB retention ratio was associated with hippocampal atrophy, which was associated with memory impairment. WMH were associated with frontal thinning, which was associated with executive and memory dysfunctions. PiB retention ratio and lacunae were also associated with memory and executive dysfunction without the mediation of hippocampal or frontal atrophy. Conclusions: Our results suggest that the impacts of AD and CVD pathologies on cognition are mediated by specific brain regions. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S1552526014024194http://hdl.handle.net/20.500.11754/24987
ISSN
1552-5260; 1552-5279
DOI
10.1016/j.jalz.2014.04.521
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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