Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2017-01-06T04:59:17Z | - |
dc.date.available | 2017-01-06T04:59:17Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | RHEUMATOLOGY INTERNATIONAL, v. 35, NO 5, Page. 815-823 | en_US |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.issn | 1437-160X | - |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs00296-014-3156-2 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24949 | - |
dc.description.abstract | The aim of this study was to determine whether the functional integrin-alpha-M (ITGAM) rs1143679 polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), lupus nephritis (LN), and rheumatoid arthritis (RA). A series of meta-analyses were conducted to test for associations between the ITGAM rs1143679 polymorphism and SLE, LN, or RA. A total of 24 comparisons involving 7,738 patients and 8,309 controls for SLE, and 2,663 patients and 2,694 controls in RA were considered. Meta-analysis showed a significant association between the ITGAM rs1143679 A allele and SLE in all subjects (OR 1.773, 95 % CI 1.656, 1.901, p ˂ 1.0 x 10(-9)). After stratification by ethnicity, the A allele was found to be significantly associated with SLE in European, Latin American, and Asian. A significant association was also found between the ITGAM A allele and lupus nephritis in Europeans (OR 2.131, 95 % CI 1.565, 2.903, p = 1.6 x 10(-7)). However, no association was found between RA and the ITGAM rs1143679 polymorphism. Our meta-analyses confirm that the ITGAM rs1143679 polymorphism is associated with SLE susceptibility in different ethnic groups and demonstrate that the polymorphism is associated with LN in European. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | ITGAM | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 35 | - |
dc.identifier.doi | 10.1007/s00296-014-3156-2 | - |
dc.relation.page | 815-823 | - |
dc.relation.journal | RHEUMATOLOGY INTERNATIONAL | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.relation.code | 2015003449 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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