Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이창호 | - |
dc.date.accessioned | 2017-01-06T02:41:38Z | - |
dc.date.available | 2017-01-06T02:41:38Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, v. 53, NO 5, Page. 363-371 | en_US |
dc.identifier.issn | 0946-1965 | - |
dc.identifier.uri | https://www.dustri.com/article_response_page.html?artId=13156&doi=10.5414/CP202226&L=0 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24943 | - |
dc.description.abstract | Objective: Tacrolimus is known to have little hepatotoxicity. Nevertheless, a few case studies have shown liver toxicities of tacrolimus, particularly in patients on multiple medications. This study is a retrospective data analysis on the potential of tacrolimus hepatotoxicity. Methods: A data analysis was conducted on the electronic medical records (EMRs) of 2,462 Korean patients taking tacrolimus or cyclosporine from 2002 through to 2008. Alanine aminotransferase (ALT) and total bilirubin level (TBL) were also monitored. The maximum ALT, time to reach ALTmax (T-ALTmax), and TBLALTmax were compared between the tacrolimus and cyclosporine groups. Other possible factors that may aggravate liver function were also investigated. Results: ALTmax and TBLALTmax were higher in the tacrolimus group compared to the cyclosporine group (i.e., 50 IU/L vs. 41 IU/L and 1 mg/dL vs. 0.9 mg/dL, respectively), and T-ALTmax was shorter (i.e., 101 days vs. 142 days) in the tacrolimus group. In addition, the frequency of ALTmax ˃ 3x upper limit of normal (ULN) (i.e., ALTmax ˃ 120) was significantly increased in the tacrolimus group compared to the cyclosporine group (30% vs. 21%). The severity of tacrolimus-induced liver damage was greater in patients with history of liver disease, as indicated by ˃ two-fold greater ALTmax than that of cyclosporine (i.e., 153 IU/L vs. 65 IU/L). Moreover, the ALTmax was significantly lowered by switching from tacrolimus to cyclosporine in patients with a history of liver disease. In patients with preexisting renal disease, neither tacrolimus nor cyclosporine showed any effect on ALTmax. Conclusion: Results indicate that tacrolimus may have a higher risk of inducing liver injury in Korean patients with a history of liver disease and may require close monitoring. | en_US |
dc.description.sponsorship | s work was supported by a fund from Seoul National University Hospital. | en_US |
dc.language.iso | en | en_US |
dc.publisher | DUSTRI-VERLAG DR KARL FEISTLE | en_US |
dc.subject | tacrolimus | en_US |
dc.subject | hepatotoxicity | en_US |
dc.subject | EMR | en_US |
dc.subject | cyclosporine | en_US |
dc.subject | ALT | en_US |
dc.title | Tacrolimus therapy causes hepatotoxicity in patients with a history of liver disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 53 | - |
dc.identifier.doi | 10.5414/CP202226 | - |
dc.relation.page | 363-371 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | - |
dc.contributor.googleauthor | Ko, Myong Suk | - |
dc.contributor.googleauthor | Choi, Young Hee | - |
dc.contributor.googleauthor | Jung, Sun Hoi | - |
dc.contributor.googleauthor | Lee, Jenny Sue | - |
dc.contributor.googleauthor | Kim, Hyang Sook | - |
dc.contributor.googleauthor | Lee, Chang H | - |
dc.contributor.googleauthor | Kim, Sang Geon | - |
dc.relation.code | 2015003347 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jennysue | - |
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