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dc.contributor.author최종훈-
dc.date.accessioned2016-12-13T05:01:11Z-
dc.date.available2016-12-13T05:01:11Z-
dc.date.issued2015-05-
dc.identifier.citationBIOSENSORS & BIOELECTRONICS, v. 72, Page. 230-236en_US
dc.identifier.issn0956-5663-
dc.identifier.issn1873-4235-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0956566315301019-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24824-
dc.description.abstractWe report the application of a fully automated surface-enhanced Raman scattering (SERS)-based solenoid-embedded microfluidic device to the quantitative and sensitive detection of anthrax biomarker poly-gamma-D-glutamic acid (PGA) in solution. Analysis is based on the competitive reaction between PGA and PGA-conjugated gold nanoparticles with anti-PGA-immobilized magnetic beads within a microfluidic environment. Magnetic immunocomplexes are trapped by yoke-type solenoids embedded within the device, and their SERS signals were directly measured and analyzed. To improve the acccuracy of measurement process, external standard values for PGA-free serum were also measured through use of a control channel. This additional measurement greatly improves the reliability of the assay by minimizing the influence of extraneous experimental variables. The limit of detection (LOD) of PGA in serum, determined by our SERS-based microfluidic sensor, is estimated to be 100 pg/mL. We believe that the defined method represents a valuable analytical tool for the detection of anthrax-related aqueous samples. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThe National Research Foundation of Korea supported this work (Grant number K20904000004-14A0500-00410). This work was partially supported by the Research Program from the Korea Centers for Disease Control and Prevention (Grant number 2014-E45002-00) and the Agency for Chemical & Biological Detection Research Center (CBDRC).en_US
dc.language.isoenen_US
dc.publisherELSEVIER ADVANCED TECHNOLOGYen_US
dc.subjectAnthraxen_US
dc.subjectSurface-enhanced Raman scatteringen_US
dc.subjectMicrofluidicsen_US
dc.subjectSolenoiden_US
dc.subjectPoly-gamma-D-glutamic aciden_US
dc.titleFast and sensitive detection of an anthrax biomarker using SERS-based solenoid microfluidic sensor.en_US
dc.typeArticleen_US
dc.relation.volume72-
dc.identifier.doi10.1016/j.bios.2015.05.005-
dc.relation.page230-236-
dc.relation.journalBIOSENSORS & BIOELECTRONICS-
dc.contributor.googleauthorGao, Rongke-
dc.contributor.googleauthorKo, Juhui-
dc.contributor.googleauthorCha, Kiweon-
dc.contributor.googleauthorJeon, Jun Ho-
dc.contributor.googleauthorRhie, Gi-eun-
dc.contributor.googleauthorChoi, Jonghoon-
dc.contributor.googleauthordeMello, Andrew J.-
dc.contributor.googleauthorChoo, Jaebum-
dc.relation.code2015001548-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidjonghchoi-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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