492 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author이민형-
dc.date.accessioned2016-12-13T02:08:31Z-
dc.date.available2016-12-13T02:08:31Z-
dc.date.issued2015-05-
dc.identifier.citationNEUROREPORT, v. 26, NO 7, Page. 399-404en_US
dc.identifier.issn0959-4965-
dc.identifier.issn1473-558X-
dc.identifier.urihttp://ovidsp.tx.ovid.com/sp-3.23.1b/ovidweb.cgi?QS2=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-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24821-
dc.description.abstractPreviously, we determined that vascular endothelial growth factor (VEGF) improves the survival of neural stem cells (NSCs) transplanted into an ischemic environment and effectively enhances angiogenesis. Here, we applied NSCs expressing VEGF (SV-VEGF-NSCs) to treat neuropathic pain. In this study, our goal was to verify the therapeutic effect of SV-VEGF-NSCs by transplanting the cells in a sciatic nerve injury model. We compared the amount of VEGF secreted from DsRed-NSCs (control) or SV-VEGF-NSCs and observed that SV-VEGF-NSCs have a much higher expression level of VEGF. We next investigated whether transplantation with SV-VEGF-NSCs aids functional recovery and pain reduction. We confirmed that transplantation with SV-VEGF-NSCs enhances functional recovery, pain reduction, and remyelination as well as the number of blood vessels compared with the control groups. Our results show that VEGF aids functional recovery and pain reduction in a sciatic nerve injury model. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.en_US
dc.description.sponsorshipThis study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A120254) and a faculty research grant from Yonsei University College of Medicine for 2014 (No. 6-2014-0021).en_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.subjectneural stem cellsen_US
dc.subjectneuropathic painen_US
dc.subjectsciatic nerve injuryen_US
dc.subjectvascular endothelial growth factoren_US
dc.titleVascular endothelial growth factor-expressing neural stem cell for the treatment of neuropathic painen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume26-
dc.identifier.doi10.1097/WNR.0000000000000359-
dc.relation.page399-404-
dc.relation.journalNEUROREPORT-
dc.contributor.googleauthorLee, Hye-Lan-
dc.contributor.googleauthorOh, Jinsoo-
dc.contributor.googleauthorYun, Yeomin-
dc.contributor.googleauthorLee, Hye Yeong-
dc.contributor.googleauthorYou, Youngsang-
dc.contributor.googleauthorChe, Lihua-
dc.contributor.googleauthorLee, Minhyung-
dc.contributor.googleauthorKim, Keung Nyun-
dc.contributor.googleauthorHa, Yoon-
dc.relation.code2015001118-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidminhyung-
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE