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dc.contributor.author김용희-
dc.date.accessioned2016-12-08T01:40:03Z-
dc.date.available2016-12-08T01:40:03Z-
dc.date.issued2015-05-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, v. 205, NO 10, Page. 120-127en_US
dc.identifier.issn0168-3659-
dc.identifier.issn1873-4995-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0168365914008335-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24743-
dc.description.abstractGene therapy by engineered nucleases is a genetic intervention being investigated for curing the hereditary disorders by targeting selected genes with specific nucleotides for establishment, suppression, abolishment of a function or correction of mutation. Here, we review the fast developing technology of targeted genome engineering using site specific programmable nucleases zinc finger nucleases (ZFNs), transcription activator like nucleases (TALENs) and cluster regulatory interspaced short palindromic repeat/CRISPR associated proteins (CRISPR/Cas) based RNA-guided DNA endonucleases (RGENs) and their different characteristics including pros and cons of genome modifications by these nucleases. We have further discussed different types of delivery methods to induce gene editing, novel development in genetic engineering other than nucleases and future prospects. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was partially supported by grants from the National Research Foundation of Korea (2014049587), the Brain Korea 21 plus program (22A20130011095), and the Korean Health Technology R&D project through the Ministry of Health & Welfare (HI13C-1938-010014).en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectEngineered nucleasesen_US
dc.subjectGenome silencing vs genome editingen_US
dc.subjectGene, protein and cell therapyen_US
dc.subjectViral and non-viral delivery systemsen_US
dc.titleCurrent and future delivery systems for engineered nucleases: ZFN, TALEN and RGENen_US
dc.typeArticleen_US
dc.relation.no10-
dc.relation.volume205-
dc.identifier.doi10.1016/j.jconrel.2014.12.036-
dc.relation.page120-127-
dc.relation.journalJOURNAL OF CONTROLLED RELEASE-
dc.contributor.googleauthorUl Ain, Qurrat-
dc.contributor.googleauthorChung, Jee Young-
dc.contributor.googleauthorKim, Yong-Hee-
dc.relation.code2015002880-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidyongheekim-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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