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Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGEN

Title
Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGEN
Author
김용희
Keywords
Engineered nucleases; Genome silencing vs genome editing; Gene, protein and cell therapy; Viral and non-viral delivery systems
Issue Date
2015-05
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v. 205, NO 10, Page. 120-127
Abstract
Gene therapy by engineered nucleases is a genetic intervention being investigated for curing the hereditary disorders by targeting selected genes with specific nucleotides for establishment, suppression, abolishment of a function or correction of mutation. Here, we review the fast developing technology of targeted genome engineering using site specific programmable nucleases zinc finger nucleases (ZFNs), transcription activator like nucleases (TALENs) and cluster regulatory interspaced short palindromic repeat/CRISPR associated proteins (CRISPR/Cas) based RNA-guided DNA endonucleases (RGENs) and their different characteristics including pros and cons of genome modifications by these nucleases. We have further discussed different types of delivery methods to induce gene editing, novel development in genetic engineering other than nucleases and future prospects. (C) 2014 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0168365914008335http://hdl.handle.net/20.500.11754/24743
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2014.12.036
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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