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Optimal energy window selection of a CZT-based small-animal SPECT for quantitative accuracy

Title
Optimal energy window selection of a CZT-based small-animal SPECT for quantitative accuracy
Author
최윤영
Keywords
Single-photon emission computed tomography; SPECT; Optimal energy window; Cadmium zinc telluride; CZT; Quantitative accuracy
Issue Date
2015-05
Publisher
ELSEVIER SCIENCE BV
Citation
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, v. 782, Page. 104-111
Abstract
Cadmium zinc telluride (CZT)-based small-animal single-photon emission computed tomography (SPECT) has desirable characteristics such as superior energy resolution, but data acquisition for SPECT imaging has been widely performed with a conventional energy window. The aim of this study was to determine the optimal energy window settings for technetium-99 m (Tc-99m) and thallium-201 (Tl-201), the most commonly used isotopes in SPECT imaging, using CZT-based small-animal SPECT for quantitative accuracy. We experimentally investigated quantitative measurements with respect to primary count rate, contrast-to-noise ratio (CNR), and scatter fraction (SF) within various energy window settings using Triumph X-SPECT. The two ways of energy window settings were considered: an on-peak window and an off-peak window. in he on-peak window setting, energy centers were set on he photopeaks. in the off-peak window setting, the ratios of energy differences between the photopeak from the lower- and higher-threshold varied from 4:6 to 3:7. In addition, the energy-window width for Tc-99m varied from 5% to 20%, and that for Tl-201 varied from 10% to 30%. The results of this study enabled us to determine the optimal energy windows for each isotope in terms of primary count rate, CNR, and SF. We selected the optimal energy window that increases the primary count rate and CNR while decreasing SF. For Tc-99m SPECT imaging, the energy window of 138-145 keV with a 5% width and off-peak ratio of 3:7 was determined to be the optimal energy window. For Tl-201 SPECT imaging, the energy window of 64-85 keV with a 30% width and off-peak ratio of 3:7 was selected as the optimal energy window. Our results demonstrated that the proper energy window should be carefully chosen based on quantitative measurements in order to take advantage of desirable characteristics of CZT-based small-animal SPECT. These results provided valuable reference information for the establishment of new protocol for CZT-based small-animal study, and may offer insights into the potential of multiple-isotope imaging with CZT-based small-animal SPECT. (C) 2015 Elsevier B.V. All rights reserved
URI
http://www.sciencedirect.com/science/article/pii/S0168900215001990http://hdl.handle.net/20.500.11754/24738
ISSN
0168-9002; 1872-9576
DOI
10.1016/j.nima.2015.02.018
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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