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Engineered ECM-like microenvironment with fibrous particles for guiding 3D-encapsulated hMSC behaviours

Title
Engineered ECM-like microenvironment with fibrous particles for guiding 3D-encapsulated hMSC behaviours
Author
신흥수
Keywords
MESENCHYMAL STEM-CELLS; LINKED ALGINATE HYDROGELS; RGD PEPTIDE; BIOLOGICAL-PROPERTIES; EXTRACELLULAR-MATRIX; SURFACE MODIFICATION; NANOFIBER SCAFFOLDS; PROLIFERATION; DIFFERENTIATION; ADHESION
Issue Date
2015-05
Publisher
ROYAL SOC CHEMISTRY
Citation
JOURNAL OF MATERIALS CHEMISTRY B, v. 3, NO 13, Page. 2732-2741
Abstract
The alginate hydrogel has been used as an attractive scaffold for tissue regeneration. In particular, its simple cross-linking, high water absorption, and biocompatibility have facilitated its utility in regulating the interaction with cells or organs. However, three-dimensional (3D) networks of the alginate hydrogel do not provide fibrous anchorage sites such as the collagen fibres in the natural extracellular matrix (ECM). This has partially limited the survival of anchorage-dependent cells in the 3D hydrogel environment. In this report, we established a hybrid hydrogel containing fibrous particles (FP) that closely mimics the ECM. The RGD peptide-coupled FP (R-FP) has a wide range of distribution and was homogeneously dispersed in the hydrogel. The encapsulated human mesenchymal stem cells in the hydrogel could bind to the R-FP presenting remarkable spreading morphology, augmented viability and differentiation. These findings may elicit the significance of a physical interaction in which the R-FP provides structural and biological cues to the cells. This strategy can be widely applicable to a variety of hydrogel systems.
URI
http://pubs.rsc.org/en/Content/ArticleLanding/2015/TB/C3TB21830A#!divAbstracthttp://hdl.handle.net/20.500.11754/24721
ISSN
2050-750X; 2050-7518
DOI
10.1039/c3tb21830a
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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