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Differences in early speech patterns between Parkinson variant of multiple system atrophy and Parkinson's disease

Title
Differences in early speech patterns between Parkinson variant of multiple system atrophy and Parkinson's disease
Author
김희태
Keywords
Multiple system atrophy; Parkinson's disease; Speech; Acoustic analysis; Perceptual analysis
Issue Date
2015-05
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BRAIN AND LANGUAGE, v. 147, Page. 14-20
Abstract
In Parkinson variant of multiple system atrophy (MSA-P), patterns of early speech impairment and their distinguishing features from Parkinson's.disease (PD) require further exploration. Here, we compared speech data among patients with early-stage MSA-P, PD, and healthy subjects using quantitative acoustic and perceptual analyses. Variables were analyzed for men and women in view of gender-specific features of speech. Acoustic analysis revealed that male patients with MSA-P exhibited more profound speech abnormalities than those with PD, regarding increased voice pitch, prolonged pause time, and reduced speech rate. This might be due to widespread pathology of MSA-P in nigrostriatal or extra-striatal structures related to speech production. Although several perceptual measures were mildly impaired in MSA-P and PD patients, none of these parameters showed a significant difference between patient groups. Detailed speech analysis using acoustic measures may help distinguish between MSA-P and PD early in the disease process. (C) 2015 Elsevier Inc. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0093934X15000930http://hdl.handle.net/20.500.11754/24638
ISSN
0093-934X; 1090-2155
DOI
10.1016/j.bandl.2015.04.007
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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