350 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author김정목-
dc.date.accessioned2016-11-29T02:27:07Z-
dc.date.available2016-11-29T02:27:07Z-
dc.date.issued2015-05-
dc.identifier.citationCARCINOGENESIS, v. 36, NO 5, Page. 553-563en_US
dc.identifier.issn0143-3334-
dc.identifier.issn1460-2180-
dc.identifier.urihttp://carcin.oxfordjournals.org/content/36/5/553-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24601-
dc.description.abstractWe know little concerning the expression of transforming growth factor-β1 (TGF-β1) and TGF-β1-induced epithelialmesenchymal transition (EMT) markers in gastric mucosa and their changes after eradication of Helicobacter pylori infection have not yet been clarified. In the present study, we compared the time course of messenger RNA (mRNA) expression of TGF-β1 and five EMT markers (Twist, Snail, Slug, vimentin and E-cadherin) in 111 controls, 55 patients with gastric dysplasia and 71 patients with early gastric cancer, following eradication of H.pylori. mRNA levels in non-cancerous gastric mucosa were measured using quantitative real time-polymerase chain reaction and the histologic findings of gastric mucosa were compared before and after eradication. The average duration of follow-up was 46.7 months (6.0–112.4). The levels of TGF-β1, Twist, Snail, Slug and vimentin mRNA, in addition to levels of CD44 detected by immunohistochemistry, showed all upregulation in patients with dysplasia or early gastric cancer compared with controls (P < 0.05); moreover, the mRNA levels of E-cadherin, an epithelial marker, were decreased in these patients compared with the control group (P < 0.001). Eradication of H.pylori reduced the expression of TGF-β1, Twist, Snail, Slug and vimentin mRNA (P-value for slope <0.001), as well as the immunohistochemical expression of CD44 (P = 0.014), whereas it enhanced the expression of E-cadherin (P-value for slope < 0.05). Thus, H.pylori infection may trigger the TGF-β1-induced EMT pathway and the emergence of gastric cancer stem cells (CSCs). Its eradication may prevent the carcinogenesis of gastric cancer by inhibiting these two pathways.en_US
dc.description.sponsorshipGlobal Core Research Center (GCRC) grant (2011-0030001) from the National Research Foundation (NRF), Ministry of Education, Science and Technology (MEST), Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.subjectGENERATES CELLSen_US
dc.subjectBREAST-CANCER;en_US
dc.titleHelicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cellsen_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume36-
dc.identifier.doi10.1093/carcin/bgv022-
dc.relation.page553-563-
dc.relation.journalCARCINOGENESIS-
dc.contributor.googleauthorChoi, Yoon Jin-
dc.contributor.googleauthorKim, Nayoung-
dc.contributor.googleauthorChang, Hyun-
dc.contributor.googleauthorLee, Hye Seung-
dc.contributor.googleauthorPark, Seon Mee-
dc.contributor.googleauthorPark, Ji Hyun-
dc.contributor.googleauthorShin, Cheol Min-
dc.contributor.googleauthorKim, Jung Mogg-
dc.contributor.googleauthorKim, Joo Sung-
dc.contributor.googleauthorLee, Dong Ho-
dc.contributor.googleauthorJung, Hyun Chae-
dc.relation.code2015002929-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjungmogg-
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE