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Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS

Title
Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS
Author
이수재
Keywords
Persistent organic pollutants; Copepod; Tigriopus japonicus; Reactive oxygen species; Developmental retardation; Reduced fecundity
Issue Date
2015-05
Publisher
ELSEVIER SCIENCE BV
Citation
AQUATIC TOXICOLOGY, v. 165, Page. 136-143
Abstract
2,2',4,4'-tetrabromodiphenyl ether #BDE-47# and perfluorooctane sulfonate #PFOS# are widely dispersed persistent organic pollutants #POPs# in the marine ecosystem. However, their toxic effects on marine organisms are still poorly understood. In this study, we investigated the effects of BDE-47 and PFOS on development and reproduction at the organismal level and reactive oxygen species #ROS# production and gene expression patterns of the defensome at the cellular level in the intertidal copepod Tigriopus japonicus. In copepods exposed to BDE-47 and PFOS, we observed developmental retardation and reduced fecundity, suggesting repercussions on in vivo endpoints through alterations to the normal molting and reproduction system of T. japonicus. BDE-47 and PFOS increased levels of ROS in T. japonicus in a concentration-dependent manner, indicating that POPs can induce oxidative stress through the generation of ROS. Additionally, transcript profiles of genes related to detoxification #e.g., CYPs#, antioxidant functions #e.g., GST-sigma, catalase, MnSOD#, apoptosis #e.g., p53, Rb#, and cellular proliferation #e.g., PCNA# were modulated over 72 h in response to BDE-47 #120 mu g/L# and PFOS #1000 mu g/L#.These findings indicate that BDE-47 and PFOS can induce oxidative stress-mediated DNA damage repair systems with transcriptional regulation of detoxification, antioxidant, and apoptosis-related genes, resulting in developmental retardation and reduced fecundity in the copepod T. japonicus. #C# 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0166445X1500171Xhttp://hdl.handle.net/20.500.11754/24448
ISSN
0166-445X; 1879-1514
DOI
10.1016/j.aquatox.2015.05.022
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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