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dc.contributor.author이상경-
dc.date.accessioned2016-11-03T02:17:46Z-
dc.date.available2016-11-03T02:17:46Z-
dc.date.issued2015-04-
dc.identifier.citationTherapeutic delivery, v. 6, NO 4, Page. 491-507en_US
dc.identifier.issn2041-5990-
dc.identifier.issn2041-6008-
dc.identifier.urihttp://www.future-science.com/doi/10.4155/tde.15.2-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24125-
dc.description.abstractRNA interference mediated gene silencing has tremendous applicability in fields ranging from basic biological research to clinical therapy. However, delivery of siRNA across the cell membrane into the cytoplasm, where the RNA silencing machinery is located, is a significant hurdle in most primary cells. Cell-penetrating peptides (CPPs), peptides that possess an intrinsic ability to translocate across cell membranes, have been explored as a means to achieve cellular delivery of siRNA. Approaches using CPPs by themselves or through incorporation into other siRNA delivery platforms have been investigated with the intent of improving cytoplasmic delivery. Here, we review the utilization of CPPs for siRNA delivery with a focus on strategies developed to enhance cellular uptake, endosomal escape and cytoplasmic localization of CPP/siRNA complexes. © 2015 Future Science Ltd.en_US
dc.language.isoenen_US
dc.publisherFuture Scienceen_US
dc.titleCationic cell-penetrating peptides as vehicles for siRNA deliveryen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume6-
dc.identifier.doi10.4155/tde.15.2-
dc.relation.page491-507-
dc.relation.journalTherapeutic delivery-
dc.contributor.googleauthorBeloor, Jagadish-
dc.contributor.googleauthorZeller, Skye-
dc.contributor.googleauthorChoi, Chang Seon-
dc.contributor.googleauthorLee, Sang-Kyung-
dc.contributor.googleauthorKumar, Priti-
dc.relation.code2015038319-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidsangkyunglee-
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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