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dc.contributor.author배상철-
dc.date.accessioned2016-10-31T05:59:36Z-
dc.date.available2016-10-31T05:59:36Z-
dc.date.issued2015-04-
dc.identifier.citationCLINICAL RHEUMATOLOGY, v. 34, NO 4, Page. 683-690en_US
dc.identifier.issn0770-3198-
dc.identifier.issn1434-9949-
dc.identifier.urihttp://link.springer.com/article/10.1007%2Fs10067-015-2904-3-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24024-
dc.description.abstractThe aim of this study was to determine whether the prolactin -1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin -1149 G/T polymorphism and susceptibility to SLE or RA using allele contrast, recessive and dominant models, and homozygote contrast. A total of 10 comparative studies, consisting of 4 SLE and 6 RA studies, involving 4252 patients and 4949 controls, were included in the meta-analysis. No association between the prolactin -1149 G allele and SLE was found when all study subjects were considered together (OR = 1.019, 95 % CI = 1.841-1.236, p = 0.845). Stratification by ethnicity also indicated no association between the prolactin G allele and SLE in either Caucasian or Latin American populations. In contrast, a significant association was observed between the prolactin G allele and RA in all subjects (OR = 1.123, 95 % CI = 1.052-1.198, p = 4.6 x 10(-5)). After stratification by ethnicity, the G allele was found to be significantly associated with RA in Caucasians (OR = 1.112, 95 % CI = 1.041-1.189, p = 0.002). Furthermore, the prolactin -1149 G/T polymorphism was found to be associated with RA in Caucasians under the dominant model and under homozygote contrast. This meta-analysis demonstrates that the prolactin -1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians.en_US
dc.description.sponsorshipThis study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).en_US
dc.language.isoenen_US
dc.publisherSPRINGER LONDON LTDen_US
dc.subjectMeta-analysisen_US
dc.subjectPolymorphismen_US
dc.subjectProlactinen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectSystemic lupus erythematosusen_US
dc.titleMeta-analysis of associations between functional prolactin-1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosusen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume34-
dc.identifier.doi10.1007/s10067-015-2904-3-
dc.relation.page683-690-
dc.relation.journalCLINICAL RHEUMATOLOGY-
dc.contributor.googleauthorLee, Young Ho-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.contributor.googleauthorSong, Gwan Gyu-
dc.relation.code2015009646-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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