Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김신규 | - |
dc.date.accessioned | 2016-10-31T01:44:02Z | - |
dc.date.available | 2016-10-31T01:44:02Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | Laboratory Medicine Online, v. 5, NO 2, Page. 106-109 | en_US |
dc.identifier.issn | 2093-6338 | - |
dc.identifier.uri | http://synapse.koreamed.org/DOIx.php?id=10.3343/lmo.2015.5.2.106 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24006 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic inflammatory disorder, which principally attacks the small joints. Several autoantibodies, such as rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody, are known to be associated with RA. Anti-proliferating cell nuclear antigen (PCNA) antibodies are mainly observed in patients with systemic lupus erythematosus (SLE). Indeed, a high titer of these antibodies is considered highly suggestive of SLE; however, anti-PCNA antibodies also appear in other autoimmune diseases. Two previous reports described RA patients with low titers of anti-PCNA antibodies, respectively. In this report, we describe a case of an RA patient exhibiting a high titer (>1:2,560) of anti-PCNA antibodies. The 56-yr-old female patient, with no underlying disease or medication history, presented with multiple joint pain and morning stiffness that had begun 6 months prior. The erythrocyte sedimentation rate (ESR) and RF were elevated (102 mm/hr and 77 IU/mL, respectively), and C-reactive protein (CRP) was 0.8 mg/dL. While the test for anti-CCP antibodies was negative, an anti-PCNA pattern (>1:2,560) and a homogeneous pattern (1:320) were detected by autoimmune target (AIT) test. The presence of anti-PCNA antibodies was subsequently confirmed using the double immunodiffusion method. The anti-dsDNA test was also positive (1:160). X-ray imaging showed soft tissue swelling of multiple joints of both hands and wrists. According to the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria, the patient was classified as having RA. This is the first case to describe high titers anti-PCNA antibodies associated with RA. | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 대한진단검사의학회 | en_US |
dc.subject | Autoantibody | en_US |
dc.subject | Proliferating cell nuclear antigen | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.title | 항Proliferating Cell Nuclear Antigen 항체 양성의 류마티스관절염 환자 1예 | en_US |
dc.title.alternative | Anti-Proliferating Cell Nuclear Antigen Antibodies Detected in Rheumatoid Arthritis: A Case Report | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 5 | - |
dc.identifier.doi | 10.3343/lmo.2015.5.2.106 | - |
dc.relation.page | 106-109 | - |
dc.relation.journal | Laboratory Medicine Online | - |
dc.contributor.googleauthor | Song, Su Dok | - |
dc.contributor.googleauthor | Kim, Think-You | - |
dc.relation.code | 2015041672 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | tykim | - |
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