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dc.contributor.author진언선-
dc.date.accessioned2016-10-21T07:43:53Z-
dc.date.available2016-10-21T07:43:53Z-
dc.date.issued2015-04-
dc.identifier.citationENVIRONMENTAL MICROBIOLOGY, v. 17, Page. 1463-1474en_US
dc.identifier.issn1462-2912-
dc.identifier.issn1462-2920-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/1462-2920.12650/abstract;jsessionid=FF2EAEDB4B21C18C165B7F4F73FA1427.f02t02-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/23910-
dc.description.abstractHarmful algal blooms (HABs) can lead to substantial socio-economic losses and extensive damage to aquatic ecosystems, drinking water sources and human health. Common algicidal techniques, including ozonation, ultrasonic treatment and dispersion of algae-killing chemicals, are unsatisfactory both economically and ecologically. This study therefore presents a novel alternative strategy for the efficient control of deleterious algae via the use of host-specific virus-like particles (VLPs) combined with chemically synthesized algicidal compounds. The capsid protein of HcRNAV34, a single-stranded RNA virus that infects the toxic dinoflagellate, Heterocapsa circularisquama, was expressed in and purified from Escherichia coli and then self-assembled into VLPsin vitro. Next, the algicidal compound, thiazolidinedione 49 (TD49), was encapsidated into HcRNAV34 VLPs for specific delivery to H. circularisquama. Consequently, HcRNAV34 VLPs demonstrated the same host selectivity as naturally occurring HcRNAV34 virions, while TD49-encapsidated VLPs showed a more potent target-specific algicidal effect than TD49 alone. These results indicate that target-specific VLPs for the delivery of cytotoxic compounds to nuisance algae might provide a safe, environmentally friendly approach for the management of HABs in aquatic ecosystems.en_US
dc.description.sponsorshipThis work was supported by the Pioneer Research Center Program through the National Research Program of Korea and funded by the Ministry of Science ICT and Future Planning (Grant No. 2008-2000122). The H. circularisquama algal strains were obtained from the Harmful Algal Bloom Division, National Research Institute of Fisheries and Environment of the Inland Sea, Hiroshima, Japan.en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectDINOFLAGELLATE HETEROCAPSA-CIRCULARISQUAMA;en_US
dc.subjectSTRANDED RNA VIRUSen_US
dc.subjectTHIAZOLIDINEDIONE DERIVATIVESen_US
dc.subjectCAPSID PROTEINen_US
dc.subjectRED TIDEen_US
dc.subjectFLOCCULATIONen_US
dc.subjectBLOOMSen_US
dc.subjectHCRNAVen_US
dc.subjectCLAYen_US
dc.subjectTD49en_US
dc.titleConstruction of target-specific virus-like particles for the delivery of algicidal compounds to harmful algaeen_US
dc.typeArticleen_US
dc.relation.volume17-
dc.identifier.doi10.1111/1462-2920.12650-
dc.relation.page1463-1474-
dc.relation.journalENVIRONMENTAL MICROBIOLOGY-
dc.contributor.googleauthorKang, Beom Sik-
dc.contributor.googleauthorEom, Chi-Yong-
dc.contributor.googleauthorKim, Wonduck-
dc.contributor.googleauthorKim, Pyoung Il-
dc.contributor.googleauthorJu, Sun Yi-
dc.contributor.googleauthorRyu, Jaewon-
dc.contributor.googleauthorHan, Gui Hwan-
dc.contributor.googleauthorOh, Jeong-Il-
dc.contributor.googleauthorCho, Hoon-
dc.contributor.googleauthorBaek, Seung Ho-
dc.contributor.googleauthorJin, EonSeon-
dc.relation.code2015000628-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidesjin-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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